Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoietic recovery following myelosuppressive injury in mic...

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Autores principales:	Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95743d5eec914dfda2ea75f85a602491
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id	oai:doaj.org-article:95743d5eec914dfda2ea75f85a602491
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spelling	oai:doaj.org-article:95743d5eec914dfda2ea75f85a6024912021-12-02T14:39:51ZEndothelial-specific inhibition of NF-κB enhances functional haematopoiesis10.1038/ncomms138292041-1723https://doaj.org/article/95743d5eec914dfda2ea75f85a6024912016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13829https://doaj.org/toc/2041-1723The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoietic recovery following myelosuppressive injury in mice.Michael G. PoulosPradeep RamalingamMichael C. GutkinMaria KleppeMichael GinsbergMichael J. P. CrowleyOlivier ElementoRoss L. LevineShahin RafiiJan KitajewskiMatthew B. GreenblattJae-Hyuck ShimJason M. ButlerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael G. Poulos Pradeep Ramalingam Michael C. Gutkin Maria Kleppe Michael Ginsberg Michael J. P. Crowley Olivier Elemento Ross L. Levine Shahin Rafii Jan Kitajewski Matthew B. Greenblatt Jae-Hyuck Shim Jason M. Butler Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
description	The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoietic recovery following myelosuppressive injury in mice.
format	article
author	Michael G. Poulos Pradeep Ramalingam Michael C. Gutkin Maria Kleppe Michael Ginsberg Michael J. P. Crowley Olivier Elemento Ross L. Levine Shahin Rafii Jan Kitajewski Matthew B. Greenblatt Jae-Hyuck Shim Jason M. Butler
author_facet	Michael G. Poulos Pradeep Ramalingam Michael C. Gutkin Maria Kleppe Michael Ginsberg Michael J. P. Crowley Olivier Elemento Ross L. Levine Shahin Rafii Jan Kitajewski Matthew B. Greenblatt Jae-Hyuck Shim Jason M. Butler
author_sort	Michael G. Poulos
title	Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
title_short	Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
title_full	Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
title_fullStr	Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
title_full_unstemmed	Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis
title_sort	endothelial-specific inhibition of nf-κb enhances functional haematopoiesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/95743d5eec914dfda2ea75f85a602491
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Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

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