Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells.

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells.

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RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prioritised as an attractive therapeutic target for the...

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Autores principales: Paul A Wilson, Sara Santos Franco, Liu He, Nicholas W Galwey, Jackie Meakin, Rebecca McIntyre, Simon M McHugh, Michael A Nolan, Sarah L Spain, Thaddeus Carlson, Mercedes Lobera, Justin P Rubio, Bill Davis, Linda C McCarthy
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9579a389fd9d4fd68176d966c4cda4dc
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