Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs

A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives...

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Autores principales:	Mark C. Howell, Ryan Green, Andrew R. McGill, Roukiah M. Kahlil, Rinku Dutta, Shyam S. Mohapatra, Subhra Mohapatra
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bioinformatics T-cells complement severe COVID-19 disease lungs Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/957c1a712a3944589695a023fb1392c3
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spelling	oai:doaj.org-article:957c1a712a3944589695a023fb1392c32021-11-30T19:09:45ZActivation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs1664-322410.3389/fimmu.2021.700705https://doaj.org/article/957c1a712a3944589695a023fb1392c32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.700705/fullhttps://doaj.org/toc/1664-3224A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives intracellular complement activation in lung cells that tracks with disease severity. However, the cellular and molecular mechanisms responsible remain unclear. To shed light on the potential mechanisms, we examined publicly available RNA-Sequencing data using CIBERSORTx and conducted a Ingenuity Pathway Analysis to address this knowledge gap. In complement to these findings, we used bioinformatics tools to analyze publicly available RNA sequencing data and found that upregulation of complement may be leading to a downregulation of T-cell activity in lungs of severe COVID-19 patients. Thus, targeting treatments aimed at the modulation of classical complement and T-cell activity may help alleviate the proinflammatory effects of COVID-19, reduce lung pathology, and increase the survival of COVID-19 patients.Mark C. HowellMark C. HowellRyan GreenRyan GreenAndrew R. McGillAndrew R. McGillAndrew R. McGillRoukiah M. KahlilRinku DuttaShyam S. MohapatraShyam S. MohapatraSubhra MohapatraSubhra MohapatraFrontiers Media S.A.articlebioinformaticsT-cellscomplementsevere COVID-19 diseaselungsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioinformatics T-cells complement severe COVID-19 disease lungs Immunologic diseases. Allergy RC581-607
spellingShingle	bioinformatics T-cells complement severe COVID-19 disease lungs Immunologic diseases. Allergy RC581-607 Mark C. Howell Mark C. Howell Ryan Green Ryan Green Andrew R. McGill Andrew R. McGill Andrew R. McGill Roukiah M. Kahlil Rinku Dutta Shyam S. Mohapatra Shyam S. Mohapatra Subhra Mohapatra Subhra Mohapatra Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs
description	A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives intracellular complement activation in lung cells that tracks with disease severity. However, the cellular and molecular mechanisms responsible remain unclear. To shed light on the potential mechanisms, we examined publicly available RNA-Sequencing data using CIBERSORTx and conducted a Ingenuity Pathway Analysis to address this knowledge gap. In complement to these findings, we used bioinformatics tools to analyze publicly available RNA sequencing data and found that upregulation of complement may be leading to a downregulation of T-cell activity in lungs of severe COVID-19 patients. Thus, targeting treatments aimed at the modulation of classical complement and T-cell activity may help alleviate the proinflammatory effects of COVID-19, reduce lung pathology, and increase the survival of COVID-19 patients.
format	article
author	Mark C. Howell Mark C. Howell Ryan Green Ryan Green Andrew R. McGill Andrew R. McGill Andrew R. McGill Roukiah M. Kahlil Rinku Dutta Shyam S. Mohapatra Shyam S. Mohapatra Subhra Mohapatra Subhra Mohapatra
author_facet	Mark C. Howell Mark C. Howell Ryan Green Ryan Green Andrew R. McGill Andrew R. McGill Andrew R. McGill Roukiah M. Kahlil Rinku Dutta Shyam S. Mohapatra Shyam S. Mohapatra Subhra Mohapatra Subhra Mohapatra
author_sort	Mark C. Howell
title	Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs
title_short	Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs
title_full	Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs
title_fullStr	Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs
title_full_unstemmed	Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs
title_sort	activation of intracellular complement in lungs of patients with severe covid-19 disease decreases t-cell activity in the lungs
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/957c1a712a3944589695a023fb1392c3
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Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs

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