The evolution of hematopoietic cells under cancer therapy

The mutational effects of chemotherapies on healthy cells are unclear. Here, the authors show that the mutational signature of platinum-based drugs -but not 5-fluorouracil- is detectable in secondary acute myeloid leukemia, implying that the clonal expansion begins after the start of therapy.

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Autores principales:	Oriol Pich, Albert Cortes-Bullich, Ferran Muiños, Marta Pratcorona, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/957ed69350be465bbc94c7e7d45fe2b7
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id	oai:doaj.org-article:957ed69350be465bbc94c7e7d45fe2b7
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spelling	oai:doaj.org-article:957ed69350be465bbc94c7e7d45fe2b72021-12-02T18:50:56ZThe evolution of hematopoietic cells under cancer therapy10.1038/s41467-021-24858-32041-1723https://doaj.org/article/957ed69350be465bbc94c7e7d45fe2b72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24858-3https://doaj.org/toc/2041-1723The mutational effects of chemotherapies on healthy cells are unclear. Here, the authors show that the mutational signature of platinum-based drugs -but not 5-fluorouracil- is detectable in secondary acute myeloid leukemia, implying that the clonal expansion begins after the start of therapy.Oriol PichAlbert Cortes-BullichFerran MuiñosMarta PratcoronaAbel Gonzalez-PerezNuria Lopez-BigasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oriol Pich Albert Cortes-Bullich Ferran Muiños Marta Pratcorona Abel Gonzalez-Perez Nuria Lopez-Bigas The evolution of hematopoietic cells under cancer therapy
description	The mutational effects of chemotherapies on healthy cells are unclear. Here, the authors show that the mutational signature of platinum-based drugs -but not 5-fluorouracil- is detectable in secondary acute myeloid leukemia, implying that the clonal expansion begins after the start of therapy.
format	article
author	Oriol Pich Albert Cortes-Bullich Ferran Muiños Marta Pratcorona Abel Gonzalez-Perez Nuria Lopez-Bigas
author_facet	Oriol Pich Albert Cortes-Bullich Ferran Muiños Marta Pratcorona Abel Gonzalez-Perez Nuria Lopez-Bigas
author_sort	Oriol Pich
title	The evolution of hematopoietic cells under cancer therapy
title_short	The evolution of hematopoietic cells under cancer therapy
title_full	The evolution of hematopoietic cells under cancer therapy
title_fullStr	The evolution of hematopoietic cells under cancer therapy
title_full_unstemmed	The evolution of hematopoietic cells under cancer therapy
title_sort	evolution of hematopoietic cells under cancer therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/957ed69350be465bbc94c7e7d45fe2b7
work_keys_str_mv	AT oriolpich theevolutionofhematopoieticcellsundercancertherapy AT albertcortesbullich theevolutionofhematopoieticcellsundercancertherapy AT ferranmuinos theevolutionofhematopoieticcellsundercancertherapy AT martapratcorona theevolutionofhematopoieticcellsundercancertherapy AT abelgonzalezperez theevolutionofhematopoieticcellsundercancertherapy AT nurialopezbigas theevolutionofhematopoieticcellsundercancertherapy AT oriolpich evolutionofhematopoieticcellsundercancertherapy AT albertcortesbullich evolutionofhematopoieticcellsundercancertherapy AT ferranmuinos evolutionofhematopoieticcellsundercancertherapy AT martapratcorona evolutionofhematopoieticcellsundercancertherapy AT abelgonzalezperez evolutionofhematopoieticcellsundercancertherapy AT nurialopezbigas evolutionofhematopoieticcellsundercancertherapy
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The evolution of hematopoietic cells under cancer therapy

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