Variation of B cell subsets with age in healthy Malawians.

Although a number of previous studies have shown that different lymphocyte subsets, including B cells, vary with age, how different B cell subsets vary with age in Malawian population has not been shown before. We recruited Malawian participants of different ages and analyzed their venous blood samp...

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Autores principales:	Wilson L Mandala, Herbert Longwe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9583d633814448fbafb71bd1a2b391d2
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spelling	oai:doaj.org-article:9583d633814448fbafb71bd1a2b391d22021-12-02T20:09:20ZVariation of B cell subsets with age in healthy Malawians.1932-620310.1371/journal.pone.0254320https://doaj.org/article/9583d633814448fbafb71bd1a2b391d22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254320https://doaj.org/toc/1932-6203Although a number of previous studies have shown that different lymphocyte subsets, including B cells, vary with age, how different B cell subsets vary with age in Malawian population has not been shown before. We recruited Malawian participants of different ages and analyzed their venous blood samples for different B cell subsets. We found that both percentage and absolute counts of B cells varied with age peaking in the 7 to 12 months age group. Proportion of naïve B cells was highest in neonates and decreased with age whereas the percentage of memory B cells was lowest in neonates and increased with age. When we zeroed in on the age band within which the proportion of B cells was highest, both classical and activated memory B cells increased with age and the naïve followed the opposite trend. These results provide additional knowledge in our understanding of the dynamics of B cell subsets in individuals of a specific ethnicity as they age.Wilson L MandalaHerbert LongwePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254320 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wilson L Mandala Herbert Longwe Variation of B cell subsets with age in healthy Malawians.
description	Although a number of previous studies have shown that different lymphocyte subsets, including B cells, vary with age, how different B cell subsets vary with age in Malawian population has not been shown before. We recruited Malawian participants of different ages and analyzed their venous blood samples for different B cell subsets. We found that both percentage and absolute counts of B cells varied with age peaking in the 7 to 12 months age group. Proportion of naïve B cells was highest in neonates and decreased with age whereas the percentage of memory B cells was lowest in neonates and increased with age. When we zeroed in on the age band within which the proportion of B cells was highest, both classical and activated memory B cells increased with age and the naïve followed the opposite trend. These results provide additional knowledge in our understanding of the dynamics of B cell subsets in individuals of a specific ethnicity as they age.
format	article
author	Wilson L Mandala Herbert Longwe
author_facet	Wilson L Mandala Herbert Longwe
author_sort	Wilson L Mandala
title	Variation of B cell subsets with age in healthy Malawians.
title_short	Variation of B cell subsets with age in healthy Malawians.
title_full	Variation of B cell subsets with age in healthy Malawians.
title_fullStr	Variation of B cell subsets with age in healthy Malawians.
title_full_unstemmed	Variation of B cell subsets with age in healthy Malawians.
title_sort	variation of b cell subsets with age in healthy malawians.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9583d633814448fbafb71bd1a2b391d2
work_keys_str_mv	AT wilsonlmandala variationofbcellsubsetswithageinhealthymalawians AT herbertlongwe variationofbcellsubsetswithageinhealthymalawians
_version_	1718375078100467712

Variation of B cell subsets with age in healthy Malawians.

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