Fecal calprotectin in healthy children aged 4–16 years
Abstract Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off l...
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Nature Portfolio
2020
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oai:doaj.org-article:95840dbf9cc8489eaaac08465ea619612021-12-02T11:41:56ZFecal calprotectin in healthy children aged 4–16 years10.1038/s41598-020-77625-72045-2322https://doaj.org/article/95840dbf9cc8489eaaac08465ea619612020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77625-7https://doaj.org/toc/2045-2322Abstract Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4–16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4–16 years. Further studies are required to validate the proposed values in clinical practice.María RocaAna Rodriguez VarelaEva CarvajalEster DonatFrancisco CanoAna ArmisenMaria Jose VayaHelena EkoffDavid HervasNiclas RydellCarmen Ribes-KoninckxNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) |
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Medicine R Science Q María Roca Ana Rodriguez Varela Eva Carvajal Ester Donat Francisco Cano Ana Armisen Maria Jose Vaya Helena Ekoff David Hervas Niclas Rydell Carmen Ribes-Koninckx Fecal calprotectin in healthy children aged 4–16 years |
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Abstract Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4–16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4–16 years. Further studies are required to validate the proposed values in clinical practice. |
format |
article |
author |
María Roca Ana Rodriguez Varela Eva Carvajal Ester Donat Francisco Cano Ana Armisen Maria Jose Vaya Helena Ekoff David Hervas Niclas Rydell Carmen Ribes-Koninckx |
author_facet |
María Roca Ana Rodriguez Varela Eva Carvajal Ester Donat Francisco Cano Ana Armisen Maria Jose Vaya Helena Ekoff David Hervas Niclas Rydell Carmen Ribes-Koninckx |
author_sort |
María Roca |
title |
Fecal calprotectin in healthy children aged 4–16 years |
title_short |
Fecal calprotectin in healthy children aged 4–16 years |
title_full |
Fecal calprotectin in healthy children aged 4–16 years |
title_fullStr |
Fecal calprotectin in healthy children aged 4–16 years |
title_full_unstemmed |
Fecal calprotectin in healthy children aged 4–16 years |
title_sort |
fecal calprotectin in healthy children aged 4–16 years |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/95840dbf9cc8489eaaac08465ea61961 |
work_keys_str_mv |
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