Fecal calprotectin in healthy children aged 4–16 years

Abstract Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off l...

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Autores principales: María Roca, Ana Rodriguez Varela, Eva Carvajal, Ester Donat, Francisco Cano, Ana Armisen, Maria Jose Vaya, Helena Ekoff, David Hervas, Niclas Rydell, Carmen Ribes-Koninckx
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/95840dbf9cc8489eaaac08465ea61961
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spelling oai:doaj.org-article:95840dbf9cc8489eaaac08465ea619612021-12-02T11:41:56ZFecal calprotectin in healthy children aged 4–16 years10.1038/s41598-020-77625-72045-2322https://doaj.org/article/95840dbf9cc8489eaaac08465ea619612020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77625-7https://doaj.org/toc/2045-2322Abstract Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4–16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4–16 years. Further studies are required to validate the proposed values in clinical practice.María RocaAna Rodriguez VarelaEva CarvajalEster DonatFrancisco CanoAna ArmisenMaria Jose VayaHelena EkoffDavid HervasNiclas RydellCarmen Ribes-KoninckxNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
María Roca
Ana Rodriguez Varela
Eva Carvajal
Ester Donat
Francisco Cano
Ana Armisen
Maria Jose Vaya
Helena Ekoff
David Hervas
Niclas Rydell
Carmen Ribes-Koninckx
Fecal calprotectin in healthy children aged 4–16 years
description Abstract Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4–16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4–16 years. Further studies are required to validate the proposed values in clinical practice.
format article
author María Roca
Ana Rodriguez Varela
Eva Carvajal
Ester Donat
Francisco Cano
Ana Armisen
Maria Jose Vaya
Helena Ekoff
David Hervas
Niclas Rydell
Carmen Ribes-Koninckx
author_facet María Roca
Ana Rodriguez Varela
Eva Carvajal
Ester Donat
Francisco Cano
Ana Armisen
Maria Jose Vaya
Helena Ekoff
David Hervas
Niclas Rydell
Carmen Ribes-Koninckx
author_sort María Roca
title Fecal calprotectin in healthy children aged 4–16 years
title_short Fecal calprotectin in healthy children aged 4–16 years
title_full Fecal calprotectin in healthy children aged 4–16 years
title_fullStr Fecal calprotectin in healthy children aged 4–16 years
title_full_unstemmed Fecal calprotectin in healthy children aged 4–16 years
title_sort fecal calprotectin in healthy children aged 4–16 years
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/95840dbf9cc8489eaaac08465ea61961
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