Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly and centrosome microtubule anchoring.

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Autores principales: Ning Huang, Yuqing Xia, Donghui Zhang, Song Wang, Yitian Bao, Runsheng He, Junlin Teng, Jianguo Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/95869170b06f433aa908d61ffb11272f
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