Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

Contact guidance on aligned substrates leads to directed cell migration through a poorly defined mechanism. Here the authors show that alignment of adhesion structures and F-actin generates anisotropic traction stress to drive directional migration, and cell-cell contact reduces force orientation an...

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Autores principales:	Arja Ray, Oscar Lee, Zaw Win, Rachel M. Edwards, Patrick W. Alford, Deok-Ho Kim, Paolo P. Provenzano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95889ff4ba5747cf995513288d87a844
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spelling	oai:doaj.org-article:95889ff4ba5747cf995513288d87a8442021-12-02T15:38:49ZAnisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration10.1038/ncomms149232041-1723https://doaj.org/article/95889ff4ba5747cf995513288d87a8442017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14923https://doaj.org/toc/2041-1723Contact guidance on aligned substrates leads to directed cell migration through a poorly defined mechanism. Here the authors show that alignment of adhesion structures and F-actin generates anisotropic traction stress to drive directional migration, and cell-cell contact reduces force orientation and directional response.Arja RayOscar LeeZaw WinRachel M. EdwardsPatrick W. AlfordDeok-Ho KimPaolo P. ProvenzanoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arja Ray Oscar Lee Zaw Win Rachel M. Edwards Patrick W. Alford Deok-Ho Kim Paolo P. Provenzano Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
description	Contact guidance on aligned substrates leads to directed cell migration through a poorly defined mechanism. Here the authors show that alignment of adhesion structures and F-actin generates anisotropic traction stress to drive directional migration, and cell-cell contact reduces force orientation and directional response.
format	article
author	Arja Ray Oscar Lee Zaw Win Rachel M. Edwards Patrick W. Alford Deok-Ho Kim Paolo P. Provenzano
author_facet	Arja Ray Oscar Lee Zaw Win Rachel M. Edwards Patrick W. Alford Deok-Ho Kim Paolo P. Provenzano
author_sort	Arja Ray
title	Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
title_short	Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
title_full	Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
title_fullStr	Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
title_full_unstemmed	Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
title_sort	anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95889ff4ba5747cf995513288d87a844
work_keys_str_mv	AT arjaray anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration AT oscarlee anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration AT zawwin anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration AT rachelmedwards anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration AT patrickwalford anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration AT deokhokim anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration AT paolopprovenzano anisotropicforcesfromspatiallyconstrainedfocaladhesionsmediatecontactguidancedirectedcellmigration
_version_	1718386061922533376

Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

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