Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Liehu Cao,1,* Weizong Weng,1,* Xiao Chen,1,* Jun Zhang,1 Qirong Zhou,1 Jin Cui,1 Yuechao Zhao,1 Jung-Woog Shin,2 Jiacan Su1 1Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Biomedical Engineerin...

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Autores principales:	Cao L, Weng W, Chen X, Zhang J, Zhou Q, Cui J, Zhao Y, Shin J, Su J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	bone cements nanoporous lithium doping magnesium silicate degradability vascularization osteogenesis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/959171813fc64a6f8e00a33e6d836be9
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spelling	oai:doaj.org-article:959171813fc64a6f8e00a33e6d836be92021-12-02T07:21:41ZPromotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate1178-2013https://doaj.org/article/959171813fc64a6f8e00a33e6d836be92017-02-01T00:00:00Zhttps://www.dovepress.com/promotion-of-in-vivo-degradability-vascularization-and-osteogenesis-of-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Liehu Cao,1,* Weizong Weng,1,* Xiao Chen,1,* Jun Zhang,1 Qirong Zhou,1 Jin Cui,1 Yuechao Zhao,1 Jung-Woog Shin,2 Jiacan Su1 1Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Biomedical Engineering, Inje University, Gimhae, Republic of Korea *These authors contributed equally to this work Abstract: Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects. Keywords: bone cements, nanoporous lithium doping magnesium silicate, degradability, vascularization, osteogenesisCao LWeng WChen XZhang JZhou QCui JZhao YShin JSu JDove Medical Pressarticlebone cementsnanoporous lithium doping magnesium silicatedegradabilityvascularizationosteogenesisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1341-1352 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone cements nanoporous lithium doping magnesium silicate degradability vascularization osteogenesis Medicine (General) R5-920
spellingShingle	bone cements nanoporous lithium doping magnesium silicate degradability vascularization osteogenesis Medicine (General) R5-920 Cao L Weng W Chen X Zhang J Zhou Q Cui J Zhao Y Shin J Su J Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
description	Liehu Cao,1,* Weizong Weng,1,* Xiao Chen,1,* Jun Zhang,1 Qirong Zhou,1 Jin Cui,1 Yuechao Zhao,1 Jung-Woog Shin,2 Jiacan Su1 1Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Biomedical Engineering, Inje University, Gimhae, Republic of Korea *These authors contributed equally to this work Abstract: Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects. Keywords: bone cements, nanoporous lithium doping magnesium silicate, degradability, vascularization, osteogenesis
format	article
author	Cao L Weng W Chen X Zhang J Zhou Q Cui J Zhao Y Shin J Su J
author_facet	Cao L Weng W Chen X Zhang J Zhou Q Cui J Zhao Y Shin J Su J
author_sort	Cao L
title	Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
title_short	Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
title_full	Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
title_fullStr	Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
title_full_unstemmed	Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
title_sort	promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/959171813fc64a6f8e00a33e6d836be9
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Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

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