The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation

T-DNA mutants have been widely used for Arabidopsis gene function characterization. Here, by characterizing a null mutant created by CRISPR, the authors show that previous reported function of H2A.W is confounded by a T-DNA insertion induced chromosomal rearrangement and reveal its role in regulatin...

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Autores principales:	Pierre Bourguet, Colette L. Picard, Ramesh Yelagandula, Thierry Pélissier, Zdravko J. Lorković, Suhua Feng, Marie-Noëlle Pouch-Pélissier, Anna Schmücker, Steven E. Jacobsen, Frédéric Berger, Olivier Mathieu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9596bb5dd9224f26a484c8b0ae24c391
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spelling	oai:doaj.org-article:9596bb5dd9224f26a484c8b0ae24c3912021-12-02T16:58:20ZThe histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation10.1038/s41467-021-22993-52041-1723https://doaj.org/article/9596bb5dd9224f26a484c8b0ae24c3912021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22993-5https://doaj.org/toc/2041-1723T-DNA mutants have been widely used for Arabidopsis gene function characterization. Here, by characterizing a null mutant created by CRISPR, the authors show that previous reported function of H2A.W is confounded by a T-DNA insertion induced chromosomal rearrangement and reveal its role in regulating heterochromatin accessibility.Pierre BourguetColette L. PicardRamesh YelagandulaThierry PélissierZdravko J. LorkovićSuhua FengMarie-Noëlle Pouch-PélissierAnna SchmückerSteven E. JacobsenFrédéric BergerOlivier MathieuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Bourguet Colette L. Picard Ramesh Yelagandula Thierry Pélissier Zdravko J. Lorković Suhua Feng Marie-Noëlle Pouch-Pélissier Anna Schmücker Steven E. Jacobsen Frédéric Berger Olivier Mathieu The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
description	T-DNA mutants have been widely used for Arabidopsis gene function characterization. Here, by characterizing a null mutant created by CRISPR, the authors show that previous reported function of H2A.W is confounded by a T-DNA insertion induced chromosomal rearrangement and reveal its role in regulating heterochromatin accessibility.
format	article
author	Pierre Bourguet Colette L. Picard Ramesh Yelagandula Thierry Pélissier Zdravko J. Lorković Suhua Feng Marie-Noëlle Pouch-Pélissier Anna Schmücker Steven E. Jacobsen Frédéric Berger Olivier Mathieu
author_facet	Pierre Bourguet Colette L. Picard Ramesh Yelagandula Thierry Pélissier Zdravko J. Lorković Suhua Feng Marie-Noëlle Pouch-Pélissier Anna Schmücker Steven E. Jacobsen Frédéric Berger Olivier Mathieu
author_sort	Pierre Bourguet
title	The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
title_short	The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
title_full	The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
title_fullStr	The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
title_full_unstemmed	The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
title_sort	histone variant h2a.w and linker histone h1 co-regulate heterochromatin accessibility and dna methylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9596bb5dd9224f26a484c8b0ae24c391
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The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation

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