$Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials$
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Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials

MR Sedghipour, R Sorkhabi, A MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranBackground: Although there have been many studies of the efficacy and safety of wavefront-guided (WF) and cross-cylinder photorefractive keratectomy (PRK), there are...

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Autores principales:	Sedghipour MR, Sorkhabi R, Mostafaei A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/959b03dcba2547f58e5504fd8fd20884
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spelling	oai:doaj.org-article:959b03dcba2547f58e5504fd8fd208842021-12-02T02:41:05ZWavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials1177-54671177-5483https://doaj.org/article/959b03dcba2547f58e5504fd8fd208842012-01-01T00:00:00Zhttp://www.dovepress.com/wavefront-guided-versus-cross-cylinder-photorefractive-keratectomy-in--a9154https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483MR Sedghipour, R Sorkhabi, A MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranBackground: Although there have been many studies of the efficacy and safety of wavefront-guided (WF) and cross-cylinder photorefractive keratectomy (PRK), there are few studies on moderate-to-high astigmatism cases. The aim of this study was to assess and compare the efficacy of WF and cross-cylinder PRK in moderate-to-high astigmatism.Methods: In a comparative cohort, the results of two before-and-after clinical trials conducted on moderate-to-high astigmatism were studied. In the first trial, 50 eyes of 25 patients with stable refraction were enrolled in a before-and-after clinical trial to undergo WF PRK using the VISX&trade; (VISX Inc, Santa Clara, CA) system. The second clinical trial enrolled 48 eyes of 24 patients with stable refraction and moderate-to-high astigmatism to undergo PRK by the cross-cylinder method using a NIDEK EC-5000 excimer laser system (NIDEK Co Ltd, Gamagori, Japan).Results: After 6 months, 80% of the eyes in the WF group had uncorrected visual acuity of 20/20 or better compared to 40% in the cross-cylinder group. Only one eye in the cross-cylinder group and no eyes in the WF group lost more than one line of best corrected visual acuity (BCVA) after 6 months of treatment. No treated eyes in either group lost more than two lines of BCVA. The percentage of eyes with no change in BCVA was 54% and 58.3% in the WF and cross-cylinder groups, respectively. Mean postoperative absolute changes in total root-mean-square higher order aberrations in the WF group and cross-cylinder group were 0.05 &plusmn; 0.22 &micro;m and 0.17 &plusmn; 0.20 &micro;m, respectively (P &lt; 0.001).Conclusion: Both methods of PRK, using the NIDEK EC-5000 and VISX excimer laser systems, are effective for correcting moderate-to-high astigmatism. The WF approach appeared more successful in improving the refractive results.Keywords: astigmatism, photorefractive keratectomy, wavefront-guided photorefractive keratectomy, cross-cylinder photorefractive keratectomySedghipour MRSorkhabi RMostafaei ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 199-204 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Sedghipour MR Sorkhabi R Mostafaei A Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
description	MR Sedghipour, R Sorkhabi, A MostafaeiNikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, IranBackground: Although there have been many studies of the efficacy and safety of wavefront-guided (WF) and cross-cylinder photorefractive keratectomy (PRK), there are few studies on moderate-to-high astigmatism cases. The aim of this study was to assess and compare the efficacy of WF and cross-cylinder PRK in moderate-to-high astigmatism.Methods: In a comparative cohort, the results of two before-and-after clinical trials conducted on moderate-to-high astigmatism were studied. In the first trial, 50 eyes of 25 patients with stable refraction were enrolled in a before-and-after clinical trial to undergo WF PRK using the VISX&trade; (VISX Inc, Santa Clara, CA) system. The second clinical trial enrolled 48 eyes of 24 patients with stable refraction and moderate-to-high astigmatism to undergo PRK by the cross-cylinder method using a NIDEK EC-5000 excimer laser system (NIDEK Co Ltd, Gamagori, Japan).Results: After 6 months, 80% of the eyes in the WF group had uncorrected visual acuity of 20/20 or better compared to 40% in the cross-cylinder group. Only one eye in the cross-cylinder group and no eyes in the WF group lost more than one line of best corrected visual acuity (BCVA) after 6 months of treatment. No treated eyes in either group lost more than two lines of BCVA. The percentage of eyes with no change in BCVA was 54% and 58.3% in the WF and cross-cylinder groups, respectively. Mean postoperative absolute changes in total root-mean-square higher order aberrations in the WF group and cross-cylinder group were 0.05 &plusmn; 0.22 &micro;m and 0.17 &plusmn; 0.20 &micro;m, respectively (P &lt; 0.001).Conclusion: Both methods of PRK, using the NIDEK EC-5000 and VISX excimer laser systems, are effective for correcting moderate-to-high astigmatism. The WF approach appeared more successful in improving the refractive results.Keywords: astigmatism, photorefractive keratectomy, wavefront-guided photorefractive keratectomy, cross-cylinder photorefractive keratectomy
format	article
author	Sedghipour MR Sorkhabi R Mostafaei A
author_facet	Sedghipour MR Sorkhabi R Mostafaei A
author_sort	Sedghipour MR
title	Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
title_short	Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
title_full	Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
title_fullStr	Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
title_full_unstemmed	Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
title_sort	wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/959b03dcba2547f58e5504fd8fd20884
work_keys_str_mv	AT sedghipourmr wavefrontguidedversuscrosscylinderphotorefractivekeratectomyinmoderatetohighastigmatismacohortoftwoconsecutiveclinicaltrials AT sorkhabir wavefrontguidedversuscrosscylinderphotorefractivekeratectomyinmoderatetohighastigmatismacohortoftwoconsecutiveclinicaltrials AT mostafaeia wavefrontguidedversuscrosscylinderphotorefractivekeratectomyinmoderatetohighastigmatismacohortoftwoconsecutiveclinicaltrials
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Wavefront-guided versus cross-cylinder photorefractive keratectomy in moderate-to-high astigmatism: a cohort of two consecutive clinical trials

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