Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

Abstract Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated macrophages and known to play an important role in metabolism and immunity. In this study, mechanism of itaconic acid functioning as an anti-inflammatory metabolite was investigated with molecular biology...

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Bibliographic Details
Main Authors: Xiaoyang Zhu, Yangyang Guo, Zhigang Liu, Jingyi Yang, Huiru Tang, Yulan Wang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/959d8c87bc274311acd4d3ae86aa21eb
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