Identification of Siglec-1 null individuals infected with HIV-1

Binding of virus, HIV-1, to cellular protein Siglec-1 is important for infection of immune cells. Here the authors show that a natural mutation leading to production of truncated Siglec-1 reduces HIV binding and infectivity transfer in vitro, but does not substantially affect infection or AIDS outco...

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Autores principales:	Javier Martinez-Picado, Paul J. McLaren, Itziar Erkizia, Maureen P. Martin, Susana Benet, Margalida Rotger, Judith Dalmau, Dan Ouchi, Steven M. Wolinsky, Sudhir Penugonda, Huldrych F. Günthard, Jacques Fellay, Mary Carrington, Nuria Izquierdo-Useros, Amalio Telenti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/959f141fdeb24fdea52d8605fca12220
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spelling	oai:doaj.org-article:959f141fdeb24fdea52d8605fca122202021-12-02T14:39:14ZIdentification of Siglec-1 null individuals infected with HIV-110.1038/ncomms124122041-1723https://doaj.org/article/959f141fdeb24fdea52d8605fca122202016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12412https://doaj.org/toc/2041-1723Binding of virus, HIV-1, to cellular protein Siglec-1 is important for infection of immune cells. Here the authors show that a natural mutation leading to production of truncated Siglec-1 reduces HIV binding and infectivity transfer in vitro, but does not substantially affect infection or AIDS outcome in patients.Javier Martinez-PicadoPaul J. McLarenItziar ErkiziaMaureen P. MartinSusana BenetMargalida RotgerJudith DalmauDan OuchiSteven M. WolinskySudhir PenugondaHuldrych F. GünthardJacques FellayMary CarringtonNuria Izquierdo-UserosAmalio TelentiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier Martinez-Picado Paul J. McLaren Itziar Erkizia Maureen P. Martin Susana Benet Margalida Rotger Judith Dalmau Dan Ouchi Steven M. Wolinsky Sudhir Penugonda Huldrych F. Günthard Jacques Fellay Mary Carrington Nuria Izquierdo-Useros Amalio Telenti Identification of Siglec-1 null individuals infected with HIV-1
description	Binding of virus, HIV-1, to cellular protein Siglec-1 is important for infection of immune cells. Here the authors show that a natural mutation leading to production of truncated Siglec-1 reduces HIV binding and infectivity transfer in vitro, but does not substantially affect infection or AIDS outcome in patients.
format	article
author	Javier Martinez-Picado Paul J. McLaren Itziar Erkizia Maureen P. Martin Susana Benet Margalida Rotger Judith Dalmau Dan Ouchi Steven M. Wolinsky Sudhir Penugonda Huldrych F. Günthard Jacques Fellay Mary Carrington Nuria Izquierdo-Useros Amalio Telenti
author_facet	Javier Martinez-Picado Paul J. McLaren Itziar Erkizia Maureen P. Martin Susana Benet Margalida Rotger Judith Dalmau Dan Ouchi Steven M. Wolinsky Sudhir Penugonda Huldrych F. Günthard Jacques Fellay Mary Carrington Nuria Izquierdo-Useros Amalio Telenti
author_sort	Javier Martinez-Picado
title	Identification of Siglec-1 null individuals infected with HIV-1
title_short	Identification of Siglec-1 null individuals infected with HIV-1
title_full	Identification of Siglec-1 null individuals infected with HIV-1
title_fullStr	Identification of Siglec-1 null individuals infected with HIV-1
title_full_unstemmed	Identification of Siglec-1 null individuals infected with HIV-1
title_sort	identification of siglec-1 null individuals infected with hiv-1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/959f141fdeb24fdea52d8605fca12220
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Identification of Siglec-1 null individuals infected with HIV-1

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