Potential role of herbal medicines as a novel approach in sepsis treatment

The growing number of deaths related to sepsis has become a major concern for past few years. Sepsis is a complex pathological reactions that is explained by series of host response to microbial insult. The resulted systemic reactions are manifested by early appearance of proinflammatory cytokines l...

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Autores principales:	Juveria Usmani, Tahira Khan, Razi Ahmad, Manju Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Natural immunomodulators Proinflammatory cytokines Hyperinflammatory cytokines Sepsis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/95a0b346e70f4c8b825f8c245f167b64
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spelling	oai:doaj.org-article:95a0b346e70f4c8b825f8c245f167b642021-11-14T04:29:58ZPotential role of herbal medicines as a novel approach in sepsis treatment0753-332210.1016/j.biopha.2021.112337https://doaj.org/article/95a0b346e70f4c8b825f8c245f167b642021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011215https://doaj.org/toc/0753-3322The growing number of deaths related to sepsis has become a major concern for past few years. Sepsis is a complex pathological reactions that is explained by series of host response to microbial insult. The resulted systemic reactions are manifested by early appearance of proinflammatory cytokines leading to hyperinflammatory phase which is followed by septic shock and death of the patient. The present study has revealed that antibiotics are not self-sufficient to control the complex mechanism of sepsis. Moreover prolonged and unnecessary administration of antibiotics may lead to antibiotic resistance to pathogens. In addition to this, immunosuppressive medications are selective and have targeted approach to certain study population. Drugs from herbal origin have shown to possess a mammoth of immunomodulatory potential by suppressing proinflammatory and anti-inflammatory cytokines exhibiting no or minimal unwanted secondary responses. Concomitantly, herbal plants tend to modulate oxidative stress level and haematological imbalance during inflammatory diseased conditions. Natural compounds have gained much attention for the treatment of several clinical complications. Considering the promising responses of medicinal plants with less/no side effects and easy procurement, comprehensive research on herbal plants to treat sepsis should be contemplated.Juveria UsmaniTahira KhanRazi AhmadManju SharmaElsevierarticleNatural immunomodulatorsProinflammatory cytokinesHyperinflammatory cytokinesSepsisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112337- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Natural immunomodulators Proinflammatory cytokines Hyperinflammatory cytokines Sepsis Therapeutics. Pharmacology RM1-950
spellingShingle	Natural immunomodulators Proinflammatory cytokines Hyperinflammatory cytokines Sepsis Therapeutics. Pharmacology RM1-950 Juveria Usmani Tahira Khan Razi Ahmad Manju Sharma Potential role of herbal medicines as a novel approach in sepsis treatment
description	The growing number of deaths related to sepsis has become a major concern for past few years. Sepsis is a complex pathological reactions that is explained by series of host response to microbial insult. The resulted systemic reactions are manifested by early appearance of proinflammatory cytokines leading to hyperinflammatory phase which is followed by septic shock and death of the patient. The present study has revealed that antibiotics are not self-sufficient to control the complex mechanism of sepsis. Moreover prolonged and unnecessary administration of antibiotics may lead to antibiotic resistance to pathogens. In addition to this, immunosuppressive medications are selective and have targeted approach to certain study population. Drugs from herbal origin have shown to possess a mammoth of immunomodulatory potential by suppressing proinflammatory and anti-inflammatory cytokines exhibiting no or minimal unwanted secondary responses. Concomitantly, herbal plants tend to modulate oxidative stress level and haematological imbalance during inflammatory diseased conditions. Natural compounds have gained much attention for the treatment of several clinical complications. Considering the promising responses of medicinal plants with less/no side effects and easy procurement, comprehensive research on herbal plants to treat sepsis should be contemplated.
format	article
author	Juveria Usmani Tahira Khan Razi Ahmad Manju Sharma
author_facet	Juveria Usmani Tahira Khan Razi Ahmad Manju Sharma
author_sort	Juveria Usmani
title	Potential role of herbal medicines as a novel approach in sepsis treatment
title_short	Potential role of herbal medicines as a novel approach in sepsis treatment
title_full	Potential role of herbal medicines as a novel approach in sepsis treatment
title_fullStr	Potential role of herbal medicines as a novel approach in sepsis treatment
title_full_unstemmed	Potential role of herbal medicines as a novel approach in sepsis treatment
title_sort	potential role of herbal medicines as a novel approach in sepsis treatment
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/95a0b346e70f4c8b825f8c245f167b64
work_keys_str_mv	AT juveriausmani potentialroleofherbalmedicinesasanovelapproachinsepsistreatment AT tahirakhan potentialroleofherbalmedicinesasanovelapproachinsepsistreatment AT raziahmad potentialroleofherbalmedicinesasanovelapproachinsepsistreatment AT manjusharma potentialroleofherbalmedicinesasanovelapproachinsepsistreatment
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Potential role of herbal medicines as a novel approach in sepsis treatment

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