DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)

Autoantibodies recognizing the cancer-retina autoantigen called recoverin (RCVRN-AutoAb) may serve as a highly specific biomarker of cancer-associated retinopathy. However, they may also be found in some cancer patients without clinical evidence of retinopathy. In the present study, dot-ELISA and We...

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Autores principales:	P. V. Belousov, Ya. I. Bobrovskaya, A. V. Bogolyubova, A. Yu. Sazykin, Yu. V. Shebzukhov, A. M. Schwartz, K. V. Lanshchakov, V. E. Vanushko, D. V. Kuprash, A. Yu. Abrosimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	recoverin autoantibodies cancer-retina antigen non-invasive follicular-patterned tumor with papillary-like nuclear features thyroid thyroid cancer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/95a2e8acecc14440a6734d4979d5cc89
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spelling	oai:doaj.org-article:95a2e8acecc14440a6734d4979d5cc892021-11-18T08:03:48ZDETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)1563-06252313-741X10.15789/1563-0625-2019-4-781-788https://doaj.org/article/95a2e8acecc14440a6734d4979d5cc892019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1656https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAutoantibodies recognizing the cancer-retina autoantigen called recoverin (RCVRN-AutoAb) may serve as a highly specific biomarker of cancer-associated retinopathy. However, they may also be found in some cancer patients without clinical evidence of retinopathy. In the present study, dot-ELISA and Western blot assays were used to demonstrate the presence of circulating RCVRN-AutoAb in 4/7 (57%) of patients with recently recognized pathological entity, non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); other thyroid tumors represented by follicular adenomas, and classical and follicular variants of papillary thyroid carcinomas, demonstrated low frequencies of RCVRN-AutoAb (0/15, 1/20 (5%) and 1/15 (7%), respectively), with no significant differences from healthy individuals (0/15). Our data implicate the circulating RCVRN-AutoAb as a potential biomarker of NIFTP capable of discrimination of this novel pathological entity from other thyroid tumors.P. V. BelousovYa. I. BobrovskayaA. V. BogolyubovaA. Yu. SazykinYu. V. ShebzukhovA. M. SchwartzK. V. LanshchakovV. E. VanushkoD. V. KuprashA. Yu. AbrosimovSPb RAACIarticlerecoverinautoantibodiescancer-retina antigennon-invasive follicular-patterned tumor with papillary-like nuclear featuresthyroidthyroid cancerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 781-788 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	recoverin autoantibodies cancer-retina antigen non-invasive follicular-patterned tumor with papillary-like nuclear features thyroid thyroid cancer Immunologic diseases. Allergy RC581-607
spellingShingle	recoverin autoantibodies cancer-retina antigen non-invasive follicular-patterned tumor with papillary-like nuclear features thyroid thyroid cancer Immunologic diseases. Allergy RC581-607 P. V. Belousov Ya. I. Bobrovskaya A. V. Bogolyubova A. Yu. Sazykin Yu. V. Shebzukhov A. M. Schwartz K. V. Lanshchakov V. E. Vanushko D. V. Kuprash A. Yu. Abrosimov DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
description	Autoantibodies recognizing the cancer-retina autoantigen called recoverin (RCVRN-AutoAb) may serve as a highly specific biomarker of cancer-associated retinopathy. However, they may also be found in some cancer patients without clinical evidence of retinopathy. In the present study, dot-ELISA and Western blot assays were used to demonstrate the presence of circulating RCVRN-AutoAb in 4/7 (57%) of patients with recently recognized pathological entity, non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); other thyroid tumors represented by follicular adenomas, and classical and follicular variants of papillary thyroid carcinomas, demonstrated low frequencies of RCVRN-AutoAb (0/15, 1/20 (5%) and 1/15 (7%), respectively), with no significant differences from healthy individuals (0/15). Our data implicate the circulating RCVRN-AutoAb as a potential biomarker of NIFTP capable of discrimination of this novel pathological entity from other thyroid tumors.
format	article
author	P. V. Belousov Ya. I. Bobrovskaya A. V. Bogolyubova A. Yu. Sazykin Yu. V. Shebzukhov A. M. Schwartz K. V. Lanshchakov V. E. Vanushko D. V. Kuprash A. Yu. Abrosimov
author_facet	P. V. Belousov Ya. I. Bobrovskaya A. V. Bogolyubova A. Yu. Sazykin Yu. V. Shebzukhov A. M. Schwartz K. V. Lanshchakov V. E. Vanushko D. V. Kuprash A. Yu. Abrosimov
author_sort	P. V. Belousov
title	DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
title_short	DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
title_full	DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
title_fullStr	DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
title_full_unstemmed	DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
title_sort	detection of autoantibodies recognizing cancerretina antigen recoverin in blood of patients with non-invasive follicular thyroid neoplasms with papillary-like nuclear features (niftp)
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/95a2e8acecc14440a6734d4979d5cc89
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DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)

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