High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.
The eri-1 gene encodes a 3' exonuclease that can negatively regulate RNA interference via siRNase activity. High-dose siRNAs (hd-siRNAs) can enhance Eri-1 expression, which in return degrade siRNAs and greatly reduces RNAi efficiency. Here we report that hd-siRNAs induce mouse Eri-1 (meri-1) ex...
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Autores principales: | Yingnan Bian, Wei Zhou, Yingchun Zhao, Xiaoping Li, Wei Geng, Ruixin Hao, Qing Yang, Weida Huang |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
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Materias: | |
Acceso en línea: | https://doaj.org/article/95a3167c43d0439a89b784b58646c9e8 |
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