Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cel...
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Nature Portfolio
2017
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oai:doaj.org-article:95a420185d6b4ba7bc31aa16884f649e2021-12-02T14:41:07ZGlutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells10.1038/s41467-017-02101-22041-1723https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02101-2https://doaj.org/toc/2041-1723Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface.Emmanuel DornierNicolas RabasLouise MitchellDavid NovoSandeep DhayadeSergi MarcoGillian MackayDavid SumptonMaria PallaresColin NixonKaren BlythIain R. MacphersonElena RaineroJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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Science Q |
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Science Q Emmanuel Dornier Nicolas Rabas Louise Mitchell David Novo Sandeep Dhayade Sergi Marco Gillian Mackay David Sumpton Maria Pallares Colin Nixon Karen Blyth Iain R. Macpherson Elena Rainero Jim C. Norman Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
description |
Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface. |
format |
article |
author |
Emmanuel Dornier Nicolas Rabas Louise Mitchell David Novo Sandeep Dhayade Sergi Marco Gillian Mackay David Sumpton Maria Pallares Colin Nixon Karen Blyth Iain R. Macpherson Elena Rainero Jim C. Norman |
author_facet |
Emmanuel Dornier Nicolas Rabas Louise Mitchell David Novo Sandeep Dhayade Sergi Marco Gillian Mackay David Sumpton Maria Pallares Colin Nixon Karen Blyth Iain R. Macpherson Elena Rainero Jim C. Norman |
author_sort |
Emmanuel Dornier |
title |
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
title_short |
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
title_full |
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
title_fullStr |
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
title_full_unstemmed |
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
title_sort |
glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e |
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