Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cel...

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Autores principales:	Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e
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spelling	oai:doaj.org-article:95a420185d6b4ba7bc31aa16884f649e2021-12-02T14:41:07ZGlutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells10.1038/s41467-017-02101-22041-1723https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02101-2https://doaj.org/toc/2041-1723Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface.Emmanuel DornierNicolas RabasLouise MitchellDavid NovoSandeep DhayadeSergi MarcoGillian MackayDavid SumptonMaria PallaresColin NixonKaren BlythIain R. MacphersonElena RaineroJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emmanuel Dornier Nicolas Rabas Louise Mitchell David Novo Sandeep Dhayade Sergi Marco Gillian Mackay David Sumpton Maria Pallares Colin Nixon Karen Blyth Iain R. Macpherson Elena Rainero Jim C. Norman Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
description	Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface.
format	article
author	Emmanuel Dornier Nicolas Rabas Louise Mitchell David Novo Sandeep Dhayade Sergi Marco Gillian Mackay David Sumpton Maria Pallares Colin Nixon Karen Blyth Iain R. Macpherson Elena Rainero Jim C. Norman
author_facet	Emmanuel Dornier Nicolas Rabas Louise Mitchell David Novo Sandeep Dhayade Sergi Marco Gillian Mackay David Sumpton Maria Pallares Colin Nixon Karen Blyth Iain R. Macpherson Elena Rainero Jim C. Norman
author_sort	Emmanuel Dornier
title	Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_short	Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_full	Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_fullStr	Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_full_unstemmed	Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_sort	glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e
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Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

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