Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cel...

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Autores principales: Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e
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spelling oai:doaj.org-article:95a420185d6b4ba7bc31aa16884f649e2021-12-02T14:41:07ZGlutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells10.1038/s41467-017-02101-22041-1723https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02101-2https://doaj.org/toc/2041-1723Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface.Emmanuel DornierNicolas RabasLouise MitchellDavid NovoSandeep DhayadeSergi MarcoGillian MackayDavid SumptonMaria PallaresColin NixonKaren BlythIain R. MacphersonElena RaineroJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emmanuel Dornier
Nicolas Rabas
Louise Mitchell
David Novo
Sandeep Dhayade
Sergi Marco
Gillian Mackay
David Sumpton
Maria Pallares
Colin Nixon
Karen Blyth
Iain R. Macpherson
Elena Rainero
Jim C. Norman
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
description Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cell surface.
format article
author Emmanuel Dornier
Nicolas Rabas
Louise Mitchell
David Novo
Sandeep Dhayade
Sergi Marco
Gillian Mackay
David Sumpton
Maria Pallares
Colin Nixon
Karen Blyth
Iain R. Macpherson
Elena Rainero
Jim C. Norman
author_facet Emmanuel Dornier
Nicolas Rabas
Louise Mitchell
David Novo
Sandeep Dhayade
Sergi Marco
Gillian Mackay
David Sumpton
Maria Pallares
Colin Nixon
Karen Blyth
Iain R. Macpherson
Elena Rainero
Jim C. Norman
author_sort Emmanuel Dornier
title Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_short Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_full Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_fullStr Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_full_unstemmed Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
title_sort glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e
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