Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stimulate matrix metalloproteases recycling to the cel...
Guardado en:
Autores principales: | Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
por: Christine Gundry, et al.
Publicado: (2017) -
Increased formate overflow is a hallmark of oxidative cancer
por: Johannes Meiser, et al.
Publicado: (2018) -
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
por: Yun-Qian Wang, et al.
Publicado: (2018) -
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
por: David Novo, et al.
Publicado: (2018) -
Cancer cells with trapped nuclei cut their way through the extracellular matrix
por: Emmanuel Dornier, et al.
Publicado: (2018)