Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

It remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the par...

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Autores principales:	Minou Djannatian, Sebastian Timmler, Martina Arends, Manja Luckner, Marie-Theres Weil, Ioannis Alexopoulos, Nicolas Snaidero, Bettina Schmid, Thomas Misgeld, Wiebke Möbius, Martina Schifferer, Elior Peles, Mikael Simons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95a5bb57aa1d4978820134d929b49f85
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spelling	oai:doaj.org-article:95a5bb57aa1d4978820134d929b49f852021-12-02T16:58:26ZTwo adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS10.1038/s41467-019-12789-z2041-1723https://doaj.org/article/95a5bb57aa1d4978820134d929b49f852019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12789-zhttps://doaj.org/toc/2041-1723It remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the paranodal axo-glial junction act jointly with molecules of the internodal domain to regulate axonal interactions and myelin wrapping, and that in the combined absence of these molecules myelin sheaths are misplaced.Minou DjannatianSebastian TimmlerMartina ArendsManja LucknerMarie-Theres WeilIoannis AlexopoulosNicolas SnaideroBettina SchmidThomas MisgeldWiebke MöbiusMartina SchiffererElior PelesMikael SimonsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minou Djannatian Sebastian Timmler Martina Arends Manja Luckner Marie-Theres Weil Ioannis Alexopoulos Nicolas Snaidero Bettina Schmid Thomas Misgeld Wiebke Möbius Martina Schifferer Elior Peles Mikael Simons Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
description	It remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the paranodal axo-glial junction act jointly with molecules of the internodal domain to regulate axonal interactions and myelin wrapping, and that in the combined absence of these molecules myelin sheaths are misplaced.
format	article
author	Minou Djannatian Sebastian Timmler Martina Arends Manja Luckner Marie-Theres Weil Ioannis Alexopoulos Nicolas Snaidero Bettina Schmid Thomas Misgeld Wiebke Möbius Martina Schifferer Elior Peles Mikael Simons
author_facet	Minou Djannatian Sebastian Timmler Martina Arends Manja Luckner Marie-Theres Weil Ioannis Alexopoulos Nicolas Snaidero Bettina Schmid Thomas Misgeld Wiebke Möbius Martina Schifferer Elior Peles Mikael Simons
author_sort	Minou Djannatian
title	Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
title_short	Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
title_full	Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
title_fullStr	Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
title_full_unstemmed	Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
title_sort	two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the cns
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/95a5bb57aa1d4978820134d929b49f85
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Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

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