A functional ultrasound brain GPS for automatic vascular-based neuronavigation

Abstract Recent advances in ultrasound imaging triggered by transmission of ultrafast plane waves have rendered functional ultrasound (fUS) imaging a valuable neuroimaging modality capable of mapping cerebral vascular networks, but also for the indirect capture of neuronal activity with high sensiti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. Nouhoum, J. Ferrier, B.-F. Osmanski, N. Ialy-Radio, S. Pezet, M. Tanter, T. Deffieux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/95a9180475ba400b9d112c92a326ae41
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:95a9180475ba400b9d112c92a326ae41
record_format	dspace
spelling	oai:doaj.org-article:95a9180475ba400b9d112c92a326ae412021-12-02T18:46:57ZA functional ultrasound brain GPS for automatic vascular-based neuronavigation10.1038/s41598-021-94764-72045-2322https://doaj.org/article/95a9180475ba400b9d112c92a326ae412021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94764-7https://doaj.org/toc/2045-2322Abstract Recent advances in ultrasound imaging triggered by transmission of ultrafast plane waves have rendered functional ultrasound (fUS) imaging a valuable neuroimaging modality capable of mapping cerebral vascular networks, but also for the indirect capture of neuronal activity with high sensitivity thanks to the neurovascular coupling. However, the expansion of fUS imaging is still limited by the difficulty to identify cerebral structures during experiments based solely on the Doppler images and the shape of the vessels. In order to tackle this challenge, this study introduces the vascular brain positioning system (BPS), a GPS of the brain. The BPS is a whole-brain neuronavigation system based on the on-the-fly automatic alignment of ultrafast ultrasensitive transcranial Power Doppler volumic images to common templates such as the Allen Mouse Brain Common Coordinates Framework. This method relies on the online registration of the complex cerebral vascular fingerprint of the studied animal to a pre-aligned reference vascular atlas, thus allowing rapid matching and identification of brain structures. We quantified the accuracy of the automatic registration using super-resolution vascular images obtained at the microscopic scale using Ultrasound Localization Microscopy and found a positioning error of 44 µm and 96 µm for intra-animal and inter-animal vascular registration, respectively. The proposed BPS approach outperforms the manual vascular landmark recognition performed by expert neuroscientists (inter-annotator errors of 215 µm and 259 µm). Using the online BPS approach coupled with the Allen Atlas, we demonstrated the capability of the system to position itself automatically over chosen anatomical structures and to obtain corresponding functional activation maps even in complex oblique planes. Finally, we show that the system can be used to acquire and estimate functional connectivity matrices automatically. The proposed functional ultrasound on-the-fly neuronavigation approach allows automatic brain navigation and could become a key asset to ensure standardized experiments and protocols for non-expert and expert researchers.M. NouhoumJ. FerrierB.-F. OsmanskiN. Ialy-RadioS. PezetM. TanterT. DeffieuxNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Nouhoum J. Ferrier B.-F. Osmanski N. Ialy-Radio S. Pezet M. Tanter T. Deffieux A functional ultrasound brain GPS for automatic vascular-based neuronavigation
description	Abstract Recent advances in ultrasound imaging triggered by transmission of ultrafast plane waves have rendered functional ultrasound (fUS) imaging a valuable neuroimaging modality capable of mapping cerebral vascular networks, but also for the indirect capture of neuronal activity with high sensitivity thanks to the neurovascular coupling. However, the expansion of fUS imaging is still limited by the difficulty to identify cerebral structures during experiments based solely on the Doppler images and the shape of the vessels. In order to tackle this challenge, this study introduces the vascular brain positioning system (BPS), a GPS of the brain. The BPS is a whole-brain neuronavigation system based on the on-the-fly automatic alignment of ultrafast ultrasensitive transcranial Power Doppler volumic images to common templates such as the Allen Mouse Brain Common Coordinates Framework. This method relies on the online registration of the complex cerebral vascular fingerprint of the studied animal to a pre-aligned reference vascular atlas, thus allowing rapid matching and identification of brain structures. We quantified the accuracy of the automatic registration using super-resolution vascular images obtained at the microscopic scale using Ultrasound Localization Microscopy and found a positioning error of 44 µm and 96 µm for intra-animal and inter-animal vascular registration, respectively. The proposed BPS approach outperforms the manual vascular landmark recognition performed by expert neuroscientists (inter-annotator errors of 215 µm and 259 µm). Using the online BPS approach coupled with the Allen Atlas, we demonstrated the capability of the system to position itself automatically over chosen anatomical structures and to obtain corresponding functional activation maps even in complex oblique planes. Finally, we show that the system can be used to acquire and estimate functional connectivity matrices automatically. The proposed functional ultrasound on-the-fly neuronavigation approach allows automatic brain navigation and could become a key asset to ensure standardized experiments and protocols for non-expert and expert researchers.
format	article
author	M. Nouhoum J. Ferrier B.-F. Osmanski N. Ialy-Radio S. Pezet M. Tanter T. Deffieux
author_facet	M. Nouhoum J. Ferrier B.-F. Osmanski N. Ialy-Radio S. Pezet M. Tanter T. Deffieux
author_sort	M. Nouhoum
title	A functional ultrasound brain GPS for automatic vascular-based neuronavigation
title_short	A functional ultrasound brain GPS for automatic vascular-based neuronavigation
title_full	A functional ultrasound brain GPS for automatic vascular-based neuronavigation
title_fullStr	A functional ultrasound brain GPS for automatic vascular-based neuronavigation
title_full_unstemmed	A functional ultrasound brain GPS for automatic vascular-based neuronavigation
title_sort	functional ultrasound brain gps for automatic vascular-based neuronavigation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95a9180475ba400b9d112c92a326ae41
work_keys_str_mv	AT mnouhoum afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT jferrier afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT bfosmanski afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT nialyradio afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT spezet afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT mtanter afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT tdeffieux afunctionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT mnouhoum functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT jferrier functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT bfosmanski functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT nialyradio functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT spezet functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT mtanter functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation AT tdeffieux functionalultrasoundbraingpsforautomaticvascularbasedneuronavigation
_version_	1718377692934438912

A functional ultrasound brain GPS for automatic vascular-based neuronavigation

Ejemplares similares