Structural correlates of affinity in fetal versus adult endplate nicotinic receptors

Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when swapped exchange function between adult and feta...

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Autores principales:	Tapan Kumar Nayak, Srirupa Chakraborty, Wenjun Zheng, Anthony Auerbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95a991b663b34923bef10ad6a9711876
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spelling	oai:doaj.org-article:95a991b663b34923bef10ad6a97118762021-12-02T16:49:43ZStructural correlates of affinity in fetal versus adult endplate nicotinic receptors10.1038/ncomms113522041-1723https://doaj.org/article/95a991b663b34923bef10ad6a97118762016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11352https://doaj.org/toc/2041-1723Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when swapped exchange function between adult and fetal AChRs.Tapan Kumar NayakSrirupa ChakrabortyWenjun ZhengAnthony AuerbachNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tapan Kumar Nayak Srirupa Chakraborty Wenjun Zheng Anthony Auerbach Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
description	Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when swapped exchange function between adult and fetal AChRs.
format	article
author	Tapan Kumar Nayak Srirupa Chakraborty Wenjun Zheng Anthony Auerbach
author_facet	Tapan Kumar Nayak Srirupa Chakraborty Wenjun Zheng Anthony Auerbach
author_sort	Tapan Kumar Nayak
title	Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
title_short	Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
title_full	Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
title_fullStr	Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
title_full_unstemmed	Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
title_sort	structural correlates of affinity in fetal versus adult endplate nicotinic receptors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/95a991b663b34923bef10ad6a9711876
work_keys_str_mv	AT tapankumarnayak structuralcorrelatesofaffinityinfetalversusadultendplatenicotinicreceptors AT srirupachakraborty structuralcorrelatesofaffinityinfetalversusadultendplatenicotinicreceptors AT wenjunzheng structuralcorrelatesofaffinityinfetalversusadultendplatenicotinicreceptors AT anthonyauerbach structuralcorrelatesofaffinityinfetalversusadultendplatenicotinicreceptors
_version_	1718383230122459136

Structural correlates of affinity in fetal versus adult endplate nicotinic receptors

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