Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

Abstract Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. W...

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Autores principales:	Kimberley E. Stuart, Anna E. King, Carmen M. Fernandez-Martos, Mathew J. Summers, James C. Vickers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/95ad1ee3bb854020a52c80314558f786
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spelling	oai:doaj.org-article:95ad1ee3bb854020a52c80314558f7862021-12-02T16:08:00ZEnvironmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model10.1038/s41598-017-03016-02045-2322https://doaj.org/article/95ad1ee3bb854020a52c80314558f7862017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03016-0https://doaj.org/toc/2045-2322Abstract Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer’s disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer’s disease need to be designed to minimise a stress response that may exacerbate brain pathology.Kimberley E. StuartAnna E. KingCarmen M. Fernandez-MartosMathew J. SummersJames C. VickersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kimberley E. Stuart Anna E. King Carmen M. Fernandez-Martos Mathew J. Summers James C. Vickers Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
description	Abstract Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer’s disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer’s disease need to be designed to minimise a stress response that may exacerbate brain pathology.
format	article
author	Kimberley E. Stuart Anna E. King Carmen M. Fernandez-Martos Mathew J. Summers James C. Vickers
author_facet	Kimberley E. Stuart Anna E. King Carmen M. Fernandez-Martos Mathew J. Summers James C. Vickers
author_sort	Kimberley E. Stuart
title	Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
title_short	Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
title_full	Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
title_fullStr	Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
title_full_unstemmed	Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
title_sort	environmental novelty exacerbates stress hormones and aβ pathology in an alzheimer’s model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95ad1ee3bb854020a52c80314558f786
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_version_	1718384672617005056

Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

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