The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea

Background: Ebola virus emerged in West Africa in December 2013. The ease of mobility, porous borders, and lack of public health infrastructure led to the largest Ebola virus disease (EVD) outbreak to date. Intervention: The 2013 EVD outbreak signalled the need for laboratory diagnostic capabilitie...

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Autores principales:	Lance D. Presser, Jeanette Coffin, Lamine Koivogui, Allan Campbell, Julian Campbell, Fatmata Barrie, Jone Ngobeh, Zein Souma, Samuel Sorie, Doris Harding, Alimou Camara, Pepe Tohonamou, Basala Traore, Frank A. Hamill, Joe Bogan, Sharon Altmann, Casey Ross, Jay Mansheim, Robert Hegerty, Scott Poynter, Scott Shearrer, Carmen Asbun, Brendan Karlstrand, Phil Davis, Jane Alam, David Roberts, Paul D. Stamper, Jean Ndjomou, Nadia Wauquier, Mohamed Koroma, Alhaji Munu, Jason McClintock, Mar Mar, True Burns, Stephen Krcha
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2021
Materias:	ebola ebola virus sierra leone guinea diagnostics laboratory capacity service expansion epidemic outbreak outbreak response west africa mobile diagnostic laboratories Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/95ad5e951b1d4b59bc6374b6ef44863d
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spelling	oai:doaj.org-article:95ad5e951b1d4b59bc6374b6ef44863d2021-11-24T07:34:27ZThe deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea2225-20022225-201010.4102/ajlm.v10i1.1414https://doaj.org/article/95ad5e951b1d4b59bc6374b6ef44863d2021-10-01T00:00:00Zhttps://ajlmonline.org/index.php/ajlm/article/view/1414https://doaj.org/toc/2225-2002https://doaj.org/toc/2225-2010Background: Ebola virus emerged in West Africa in December 2013. The ease of mobility, porous borders, and lack of public health infrastructure led to the largest Ebola virus disease (EVD) outbreak to date. Intervention: The 2013 EVD outbreak signalled the need for laboratory diagnostic capabilities in areas without strong public health systems. As part of the United States’ Department of Defense response, MRIGlobal was contracted to design, fabricate, equip, deploy, and operate two mobile diagnostic laboratories (MDLs). The first laboratory analysed blood samples from patients in an adjacent Ebola Treatment Centre (ETC) and buccal swabs from the deceased in the community in Moyamba, Sierra Leone. The second laboratory was deployed to support an ETC in Conakry, Guinea. The Department of Defense provided real-time quantitative reverse transcription polymerase chain reaction assays that were deployed and validated on-site. Lessons Learnt: Prompt and accurate molecular diagnostics reduced sample turn-around times from over 24 h to under 4 h. Experienced laboratory staff tested up to 110 samples per day and on-site engineering proved necessary for MDL setup and operation. As the Ebola response slowed, the sustainment of the MDLs’ operations was prioritised, including staff training and the transition of the MDLs to local governments. Training programmes for local staff were prepared in Sierra Leone and Guinea. Recommendations: The MRIGlobal MDL team significantly contributed to establishing increased laboratory capacity during the EVD outbreak in West Africa. Using the MDLs for molecular diagnosis is highly recommended until more sustainable solutions can be provided.Lance D. PresserJeanette CoffinLamine KoivoguiAllan CampbellJulian CampbellFatmata BarrieJone NgobehZein SoumaSamuel SorieDoris HardingAlimou CamaraPepe TohonamouBasala TraoreFrank A. HamillJoe BoganSharon AltmannCasey RossJay MansheimRobert HegertyScott PoynterScott ShearrerCarmen AsbunBrendan KarlstrandPhil DavisJane AlamDavid RobertsPaul D. StamperJean NdjomouNadia WauquierMohamed KoromaAlhaji MunuJason McClintockMar MarTrue BurnsStephen KrchaAOSISarticleebolaebola virussierra leoneguineadiagnosticslaboratory capacityservice expansionepidemicoutbreakoutbreak responsewest africamobile diagnostic laboratoriesPublic aspects of medicineRA1-1270ENAfrican Journal of Laboratory Medicine, Vol 10, Iss 1, Pp e1-e6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ebola ebola virus sierra leone guinea diagnostics laboratory capacity service expansion epidemic outbreak outbreak response west africa mobile diagnostic laboratories Public aspects of medicine RA1-1270
spellingShingle	ebola ebola virus sierra leone guinea diagnostics laboratory capacity service expansion epidemic outbreak outbreak response west africa mobile diagnostic laboratories Public aspects of medicine RA1-1270 Lance D. Presser Jeanette Coffin Lamine Koivogui Allan Campbell Julian Campbell Fatmata Barrie Jone Ngobeh Zein Souma Samuel Sorie Doris Harding Alimou Camara Pepe Tohonamou Basala Traore Frank A. Hamill Joe Bogan Sharon Altmann Casey Ross Jay Mansheim Robert Hegerty Scott Poynter Scott Shearrer Carmen Asbun Brendan Karlstrand Phil Davis Jane Alam David Roberts Paul D. Stamper Jean Ndjomou Nadia Wauquier Mohamed Koroma Alhaji Munu Jason McClintock Mar Mar True Burns Stephen Krcha The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
description	Background: Ebola virus emerged in West Africa in December 2013. The ease of mobility, porous borders, and lack of public health infrastructure led to the largest Ebola virus disease (EVD) outbreak to date. Intervention: The 2013 EVD outbreak signalled the need for laboratory diagnostic capabilities in areas without strong public health systems. As part of the United States’ Department of Defense response, MRIGlobal was contracted to design, fabricate, equip, deploy, and operate two mobile diagnostic laboratories (MDLs). The first laboratory analysed blood samples from patients in an adjacent Ebola Treatment Centre (ETC) and buccal swabs from the deceased in the community in Moyamba, Sierra Leone. The second laboratory was deployed to support an ETC in Conakry, Guinea. The Department of Defense provided real-time quantitative reverse transcription polymerase chain reaction assays that were deployed and validated on-site. Lessons Learnt: Prompt and accurate molecular diagnostics reduced sample turn-around times from over 24 h to under 4 h. Experienced laboratory staff tested up to 110 samples per day and on-site engineering proved necessary for MDL setup and operation. As the Ebola response slowed, the sustainment of the MDLs’ operations was prioritised, including staff training and the transition of the MDLs to local governments. Training programmes for local staff were prepared in Sierra Leone and Guinea. Recommendations: The MRIGlobal MDL team significantly contributed to establishing increased laboratory capacity during the EVD outbreak in West Africa. Using the MDLs for molecular diagnosis is highly recommended until more sustainable solutions can be provided.
format	article
author	Lance D. Presser Jeanette Coffin Lamine Koivogui Allan Campbell Julian Campbell Fatmata Barrie Jone Ngobeh Zein Souma Samuel Sorie Doris Harding Alimou Camara Pepe Tohonamou Basala Traore Frank A. Hamill Joe Bogan Sharon Altmann Casey Ross Jay Mansheim Robert Hegerty Scott Poynter Scott Shearrer Carmen Asbun Brendan Karlstrand Phil Davis Jane Alam David Roberts Paul D. Stamper Jean Ndjomou Nadia Wauquier Mohamed Koroma Alhaji Munu Jason McClintock Mar Mar True Burns Stephen Krcha
author_facet	Lance D. Presser Jeanette Coffin Lamine Koivogui Allan Campbell Julian Campbell Fatmata Barrie Jone Ngobeh Zein Souma Samuel Sorie Doris Harding Alimou Camara Pepe Tohonamou Basala Traore Frank A. Hamill Joe Bogan Sharon Altmann Casey Ross Jay Mansheim Robert Hegerty Scott Poynter Scott Shearrer Carmen Asbun Brendan Karlstrand Phil Davis Jane Alam David Roberts Paul D. Stamper Jean Ndjomou Nadia Wauquier Mohamed Koroma Alhaji Munu Jason McClintock Mar Mar True Burns Stephen Krcha
author_sort	Lance D. Presser
title	The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
title_short	The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
title_full	The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
title_fullStr	The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
title_full_unstemmed	The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
title_sort	deployment of mobile diagnostic laboratories for ebola virus disease diagnostics in sierra leone and guinea
publisher	AOSIS
publishDate	2021
url	https://doaj.org/article/95ad5e951b1d4b59bc6374b6ef44863d
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The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea

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