Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vi...

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Autores principales:	Michael S. Nakazawa, T. S. Karin Eisinger-Mathason, Navid Sadri, Joshua D. Ochocki, Terence P. F. Gade, Ruchi K. Amin, M. Celeste Simon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95b0d41802c54d1d8d017de48e65cd93
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spelling	oai:doaj.org-article:95b0d41802c54d1d8d017de48e65cd932021-12-02T15:34:11ZEpigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth10.1038/ncomms105392041-1723https://doaj.org/article/95b0d41802c54d1d8d017de48e65cd932016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10539https://doaj.org/toc/2041-1723Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vivo.Michael S. NakazawaT. S. Karin Eisinger-MathasonNavid SadriJoshua D. OchockiTerence P. F. GadeRuchi K. AminM. Celeste SimonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael S. Nakazawa T. S. Karin Eisinger-Mathason Navid Sadri Joshua D. Ochocki Terence P. F. Gade Ruchi K. Amin M. Celeste Simon Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
description	Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vivo.
format	article
author	Michael S. Nakazawa T. S. Karin Eisinger-Mathason Navid Sadri Joshua D. Ochocki Terence P. F. Gade Ruchi K. Amin M. Celeste Simon
author_facet	Michael S. Nakazawa T. S. Karin Eisinger-Mathason Navid Sadri Joshua D. Ochocki Terence P. F. Gade Ruchi K. Amin M. Celeste Simon
author_sort	Michael S. Nakazawa
title	Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_short	Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_full	Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_fullStr	Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_full_unstemmed	Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
title_sort	epigenetic re-expression of hif-2α suppresses soft tissue sarcoma growth
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/95b0d41802c54d1d8d017de48e65cd93
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Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

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