CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation

Yunli Xing, Ying Sun, Hongwei Li, Mei Tang, Wei Huang, Kan Zhang, Dai Zhang, Deqiang Zhang, Qing Ma Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Background: The CHA2DS2-VASc score is often used for...

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Autores principales: Xing Y, Sun Y, Li H, Tang M, Huang W, Zhang K, Zhang D, Ma Q
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:95b0fe48c9ce48aba5acfe9eb3c1c4232021-12-02T00:21:56ZCHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation1178-1998https://doaj.org/article/95b0fe48c9ce48aba5acfe9eb3c1c4232018-03-01T00:00:00Zhttps://www.dovepress.com/cha2ds2-vasc-score-as-a-predictor-of-long-term-cardiac-outcomes-in-eld-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yunli Xing, Ying Sun, Hongwei Li, Mei Tang, Wei Huang, Kan Zhang, Dai Zhang, Deqiang Zhang, Qing Ma Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Background: The CHA2DS2-VASc score is often used for stroke risk stratification in atrial fibrillation (AF) patients. However, its usefulness in patients ≥75 years of age with or without AF is unclear.Objective: We aimed to investigate whether the CHA2DS2-VASc score can predict ischemic stroke (IS), transient ischemic attack, thromboembolism (TE), and mortality in elderly patients with and without AF.Materials and methods: During 2013–2014, 1,071 patients (36.3% with concomitant AF) at least 75 years old were enrolled, and the follow-up ended on July 15, 2017. Variables included sociodemographic characteristics, complications, drugs taken, laboratory results, and echocardiographic parameters. The primary end points were IS, transient ischemic attack, and TE, expressed as IS/TE. All-cause mortality was a secondary end point. Survival curves and mortality risks were assessed via Kaplan–Meier survival analysis and compared by log-rank tests.Results: The average follow-up duration was 2.57±1.37 years. Overall, 167 patients (5.6%) died and 77 (7.2%) developed IS/TE. The CHA2DS2-VASc score was associated with IS/TE in patients 75 years or older with and without AF, and patients with a CHA2DS2-VASc score ≥5 had a higher risk of stroke. However, the CHA2DS2-VASc score was not related to all-cause mortality.Conclusion: The CHA2DS2-VASc score can predict IS/TE, but not mortality, in elderly patients (≥75 years) with or without AF. Keywords: CHA2DS2-VASc score, atrial fibrillation, elderly, stroke, survivalXing YSun YLi HTang MHuang WZhang KZhang DZhang DMa QDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 497-504 (2018)
institution DOAJ
collection DOAJ
language EN
topic Geriatrics
RC952-954.6
spellingShingle Geriatrics
RC952-954.6
Xing Y
Sun Y
Li H
Tang M
Huang W
Zhang K
Zhang D
Zhang D
Ma Q
CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
description Yunli Xing, Ying Sun, Hongwei Li, Mei Tang, Wei Huang, Kan Zhang, Dai Zhang, Deqiang Zhang, Qing Ma Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Background: The CHA2DS2-VASc score is often used for stroke risk stratification in atrial fibrillation (AF) patients. However, its usefulness in patients ≥75 years of age with or without AF is unclear.Objective: We aimed to investigate whether the CHA2DS2-VASc score can predict ischemic stroke (IS), transient ischemic attack, thromboembolism (TE), and mortality in elderly patients with and without AF.Materials and methods: During 2013–2014, 1,071 patients (36.3% with concomitant AF) at least 75 years old were enrolled, and the follow-up ended on July 15, 2017. Variables included sociodemographic characteristics, complications, drugs taken, laboratory results, and echocardiographic parameters. The primary end points were IS, transient ischemic attack, and TE, expressed as IS/TE. All-cause mortality was a secondary end point. Survival curves and mortality risks were assessed via Kaplan–Meier survival analysis and compared by log-rank tests.Results: The average follow-up duration was 2.57±1.37 years. Overall, 167 patients (5.6%) died and 77 (7.2%) developed IS/TE. The CHA2DS2-VASc score was associated with IS/TE in patients 75 years or older with and without AF, and patients with a CHA2DS2-VASc score ≥5 had a higher risk of stroke. However, the CHA2DS2-VASc score was not related to all-cause mortality.Conclusion: The CHA2DS2-VASc score can predict IS/TE, but not mortality, in elderly patients (≥75 years) with or without AF. Keywords: CHA2DS2-VASc score, atrial fibrillation, elderly, stroke, survival
format article
author Xing Y
Sun Y
Li H
Tang M
Huang W
Zhang K
Zhang D
Zhang D
Ma Q
author_facet Xing Y
Sun Y
Li H
Tang M
Huang W
Zhang K
Zhang D
Zhang D
Ma Q
author_sort Xing Y
title CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
title_short CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
title_full CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
title_fullStr CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
title_full_unstemmed CHA2DS2-VASc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
title_sort cha2ds2-vasc score as a predictor of long-term cardiac outcomes in elderly patients with or without atrial fibrillation
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/95b0fe48c9ce48aba5acfe9eb3c1c423
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