Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

Abstract Background Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative spirometric equations from a representative population of Cameroonian c...

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Autores principales:	Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Virginie Poka-Mayap, Amadou Djenabou, Massongo Massongo, Nguetsa Arsene Ofimboudem, Catherine Fanny Mayoh-Nguemfo, Antoinette Ghislaine Tsala, Halidou Hadjara, Francine Amougou
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Spirometry Normal lung function Reference values Central Africa Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/95b1507d5456481eb2a95f7d7cfd0dcb
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spelling	oai:doaj.org-article:95b1507d5456481eb2a95f7d7cfd0dcb2021-11-08T11:13:28ZSpirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method10.1186/s12890-021-01705-11471-2466https://doaj.org/article/95b1507d5456481eb2a95f7d7cfd0dcb2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01705-1https://doaj.org/toc/1471-2466Abstract Background Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative spirometric equations from a representative population of Cameroonian children and adults and compare these equations with those developed by the Global Lung Initiative (GLI) and in Nigerians. Methods Spirometric data from healthy Cameroonians aged 4–89 years randomly collected between 2014 and 2018 were used to derive reference equations using generalized additive model for location (mu), shape (lambda) and scale (sigma). Results A total of 625 children and adolescents (290 males and 335 females) and 1152 adults (552 males and 600 females) were included in the study. The prediction equation for spirometric index was written as: M = Exp[a0 + a1ln (Height) + a2ln (Age) + Mspline, Mspline was age related spline contribution]. Applying the GLI standards for African Americans resulted in overall values greater than those found in our study for forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC). These values were very close in children and adolescents while the values obtained with the GLI equations for African Americans were significantly higher in adults. FEV1/FVC ratio in our study was similar for adult males but lower in adult females (88% vs 85%, difference = + 3.5%) when applying Nigerian standards. Conclusions FEV1 and FVC of the Cameroonian infant and adolescent population are very close to those of black Americans. However, FEV1 and FVC of Cameroonian adults are significantly lower than those of black American adults. These equations should allow a more suitable interpretation of spirometry in the Cameroonian population.Eric Walter Pefura-YoneAdamou Dodo BalkissouVirginie Poka-MayapAmadou DjenabouMassongo MassongoNguetsa Arsene OfimboudemCatherine Fanny Mayoh-NguemfoAntoinette Ghislaine TsalaHalidou HadjaraFrancine AmougouBMCarticleSpirometryNormal lung functionReference valuesCentral AfricaDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spirometry Normal lung function Reference values Central Africa Diseases of the respiratory system RC705-779
spellingShingle	Spirometry Normal lung function Reference values Central Africa Diseases of the respiratory system RC705-779 Eric Walter Pefura-Yone Adamou Dodo Balkissou Virginie Poka-Mayap Amadou Djenabou Massongo Massongo Nguetsa Arsene Ofimboudem Catherine Fanny Mayoh-Nguemfo Antoinette Ghislaine Tsala Halidou Hadjara Francine Amougou Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method
description	Abstract Background Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative spirometric equations from a representative population of Cameroonian children and adults and compare these equations with those developed by the Global Lung Initiative (GLI) and in Nigerians. Methods Spirometric data from healthy Cameroonians aged 4–89 years randomly collected between 2014 and 2018 were used to derive reference equations using generalized additive model for location (mu), shape (lambda) and scale (sigma). Results A total of 625 children and adolescents (290 males and 335 females) and 1152 adults (552 males and 600 females) were included in the study. The prediction equation for spirometric index was written as: M = Exp[a0 + a1ln (Height) + a2ln (Age) + Mspline, Mspline was age related spline contribution]. Applying the GLI standards for African Americans resulted in overall values greater than those found in our study for forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC). These values were very close in children and adolescents while the values obtained with the GLI equations for African Americans were significantly higher in adults. FEV1/FVC ratio in our study was similar for adult males but lower in adult females (88% vs 85%, difference = + 3.5%) when applying Nigerian standards. Conclusions FEV1 and FVC of the Cameroonian infant and adolescent population are very close to those of black Americans. However, FEV1 and FVC of Cameroonian adults are significantly lower than those of black American adults. These equations should allow a more suitable interpretation of spirometry in the Cameroonian population.
format	article
author	Eric Walter Pefura-Yone Adamou Dodo Balkissou Virginie Poka-Mayap Amadou Djenabou Massongo Massongo Nguetsa Arsene Ofimboudem Catherine Fanny Mayoh-Nguemfo Antoinette Ghislaine Tsala Halidou Hadjara Francine Amougou
author_facet	Eric Walter Pefura-Yone Adamou Dodo Balkissou Virginie Poka-Mayap Amadou Djenabou Massongo Massongo Nguetsa Arsene Ofimboudem Catherine Fanny Mayoh-Nguemfo Antoinette Ghislaine Tsala Halidou Hadjara Francine Amougou
author_sort	Eric Walter Pefura-Yone
title	Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method
title_short	Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method
title_full	Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method
title_fullStr	Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method
title_full_unstemmed	Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method
title_sort	spirometric reference equations for cameroonians aged 4 to 89 years derived using lambda, mu, sigma (lms) method
publisher	BMC
publishDate	2021
url	https://doaj.org/article/95b1507d5456481eb2a95f7d7cfd0dcb
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Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

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