Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries

Alternative splicing is regulated by multiple mechanisms. Here the authors employed designed splice site libraries and massively parallel reporter assays to dissect the regulatory complexity and cell-to-cell variability of splicing decisions and to build accurate predictive models.

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Autores principales:	Martin Mikl, Amit Hamburg, Yitzhak Pilpel, Eran Segal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95b4244dfa974dfc918f1c413b6e0f69
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:95b4244dfa974dfc918f1c413b6e0f692021-12-02T17:31:38ZDissecting splicing decisions and cell-to-cell variability with designed sequence libraries10.1038/s41467-019-12642-32041-1723https://doaj.org/article/95b4244dfa974dfc918f1c413b6e0f692019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12642-3https://doaj.org/toc/2041-1723Alternative splicing is regulated by multiple mechanisms. Here the authors employed designed splice site libraries and massively parallel reporter assays to dissect the regulatory complexity and cell-to-cell variability of splicing decisions and to build accurate predictive models.Martin MiklAmit HamburgYitzhak PilpelEran SegalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Mikl Amit Hamburg Yitzhak Pilpel Eran Segal Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
description	Alternative splicing is regulated by multiple mechanisms. Here the authors employed designed splice site libraries and massively parallel reporter assays to dissect the regulatory complexity and cell-to-cell variability of splicing decisions and to build accurate predictive models.
format	article
author	Martin Mikl Amit Hamburg Yitzhak Pilpel Eran Segal
author_facet	Martin Mikl Amit Hamburg Yitzhak Pilpel Eran Segal
author_sort	Martin Mikl
title	Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
title_short	Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
title_full	Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
title_fullStr	Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
title_full_unstemmed	Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
title_sort	dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/95b4244dfa974dfc918f1c413b6e0f69
work_keys_str_mv	AT martinmikl dissectingsplicingdecisionsandcelltocellvariabilitywithdesignedsequencelibraries AT amithamburg dissectingsplicingdecisionsandcelltocellvariabilitywithdesignedsequencelibraries AT yitzhakpilpel dissectingsplicingdecisionsandcelltocellvariabilitywithdesignedsequencelibraries AT eransegal dissectingsplicingdecisionsandcelltocellvariabilitywithdesignedsequencelibraries
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Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries

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