Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections

A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administratio...

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Autores principales: M. P. Kostinov, M. A. Ignatieva, S. V. Novikova, A. D. Shmitko, V. B. Polischuk, N. K. Akhmatova, A. A. Savisko, A. M. Kostinov
Formato: article
Lenguaje:RU
Publicado: Sankt-Peterburg : NIIÈM imeni Pastera 2020
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Acceso en línea:https://doaj.org/article/95b57d00aaee4fef86890c598c9ed210
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Sumario:A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administration of vitamin D and interferon α-2b preparations in combination with antibacterial therapy in pregnant women with bacterial vaginosis conferred anti-inflammatory effect resulting in normalized IL-8 level corresponding to that one in healthy subjects. Use of vitamin D altered interferon status and augmented antimicrobial activity in pregnant women confirmed by reduced rate of ARI episodes.