Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections

A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administratio...

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Autores principales:	M. P. Kostinov, M. A. Ignatieva, S. V. Novikova, A. D. Shmitko, V. B. Polischuk, N. K. Akhmatova, A. A. Savisko, A. M. Kostinov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	pregnant women vitamin d vaginal infections cytokines interferons Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/95b57d00aaee4fef86890c598c9ed210
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spelling	oai:doaj.org-article:95b57d00aaee4fef86890c598c9ed2102021-11-22T07:09:54ZEffect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections2220-76192313-739810.15789/10.15789/2220-7619-EOV-1140https://doaj.org/article/95b57d00aaee4fef86890c598c9ed2102020-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1140https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administration of vitamin D and interferon α-2b preparations in combination with antibacterial therapy in pregnant women with bacterial vaginosis conferred anti-inflammatory effect resulting in normalized IL-8 level corresponding to that one in healthy subjects. Use of vitamin D altered interferon status and augmented antimicrobial activity in pregnant women confirmed by reduced rate of ARI episodes.M. P. KostinovM. A. IgnatievaS. V. NovikovaA. D. ShmitkoV. B. PolischukN. K. AkhmatovaA. A. SaviskoA. M. KostinovSankt-Peterburg : NIIÈM imeni Pasteraarticlepregnant womenvitamin dvaginal infectionscytokinesinterferonsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 3, Pp 524-532 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	pregnant women vitamin d vaginal infections cytokines interferons Infectious and parasitic diseases RC109-216
spellingShingle	pregnant women vitamin d vaginal infections cytokines interferons Infectious and parasitic diseases RC109-216 M. P. Kostinov M. A. Ignatieva S. V. Novikova A. D. Shmitko V. B. Polischuk N. K. Akhmatova A. A. Savisko A. M. Kostinov Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
description	A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administration of vitamin D and interferon α-2b preparations in combination with antibacterial therapy in pregnant women with bacterial vaginosis conferred anti-inflammatory effect resulting in normalized IL-8 level corresponding to that one in healthy subjects. Use of vitamin D altered interferon status and augmented antimicrobial activity in pregnant women confirmed by reduced rate of ARI episodes.
format	article
author	M. P. Kostinov M. A. Ignatieva S. V. Novikova A. D. Shmitko V. B. Polischuk N. K. Akhmatova A. A. Savisko A. M. Kostinov
author_facet	M. P. Kostinov M. A. Ignatieva S. V. Novikova A. D. Shmitko V. B. Polischuk N. K. Akhmatova A. A. Savisko A. M. Kostinov
author_sort	M. P. Kostinov
title	Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
title_short	Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
title_full	Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
title_fullStr	Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
title_full_unstemmed	Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
title_sort	effect of vitamin d and interferon α-2b on cytokine profile in pregnant women with vaginal infections
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/95b57d00aaee4fef86890c598c9ed210
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Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections

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