PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract. Prevalence of TNFα gene promoter polymorphism at -857 position was investigated in normal persons and among patients with rheumatoid arthritis. We detected a relation of this polymorphism to the levels of TNFα production by mononuclear cells of healthy donors. Changes in relative frequenci...

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Autores principales:	A. N. Silkov, N. S. Shkaruba, T. A. Kalashnikova, L. P. Sizyakina, J. B. Shulman, S. V. Dolgikh, V. I. Mazurov, O. A. Gerzog, A. E. Sizikov, V. A. Kozlov, S. V. Sennikov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	allelic polymorphism tnfα, rheumatoid arthritis anticytokine therapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/95b6b45dc0704e0f90fa95372ca01f96
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spelling	oai:doaj.org-article:95b6b45dc0704e0f90fa95372ca01f962021-11-18T08:03:40ZPROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2012-1-2-81-86https://doaj.org/article/95b6b45dc0704e0f90fa95372ca01f962014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/300https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Prevalence of TNFα gene promoter polymorphism at -857 position was investigated in normal persons and among patients with rheumatoid arthritis. We detected a relation of this polymorphism to the levels of TNFα production by mononuclear cells of healthy donors. Changes in relative frequencies of the TNFα genotypes have been shown in rheumatoid arthritis. The -857С>T polymorphism of TNFα gene proved to be informative as a molecular marker reflecting efficiency of anti-TNFα therapy in rheumatoid arthritis.A. N. SilkovN. S. ShkarubaT. A. KalashnikovaL. P. SizyakinaJ. B. ShulmanS. V. DolgikhV. I. MazurovO. A. GerzogA. E. SizikovV. A. KozlovS. V. SennikovSPb RAACIarticleallelic polymorphismtnfα, rheumatoid arthritisanticytokine therapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 81-86 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	allelic polymorphism tnfα, rheumatoid arthritis anticytokine therapy Immunologic diseases. Allergy RC581-607
spellingShingle	allelic polymorphism tnfα, rheumatoid arthritis anticytokine therapy Immunologic diseases. Allergy RC581-607 A. N. Silkov N. S. Shkaruba T. A. Kalashnikova L. P. Sizyakina J. B. Shulman S. V. Dolgikh V. I. Mazurov O. A. Gerzog A. E. Sizikov V. A. Kozlov S. V. Sennikov PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS
description	Abstract. Prevalence of TNFα gene promoter polymorphism at -857 position was investigated in normal persons and among patients with rheumatoid arthritis. We detected a relation of this polymorphism to the levels of TNFα production by mononuclear cells of healthy donors. Changes in relative frequencies of the TNFα genotypes have been shown in rheumatoid arthritis. The -857С>T polymorphism of TNFα gene proved to be informative as a molecular marker reflecting efficiency of anti-TNFα therapy in rheumatoid arthritis.
format	article
author	A. N. Silkov N. S. Shkaruba T. A. Kalashnikova L. P. Sizyakina J. B. Shulman S. V. Dolgikh V. I. Mazurov O. A. Gerzog A. E. Sizikov V. A. Kozlov S. V. Sennikov
author_facet	A. N. Silkov N. S. Shkaruba T. A. Kalashnikova L. P. Sizyakina J. B. Shulman S. V. Dolgikh V. I. Mazurov O. A. Gerzog A. E. Sizikov V. A. Kozlov S. V. Sennikov
author_sort	A. N. Silkov
title	PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_short	PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_full	PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_fullStr	PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_full_unstemmed	PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_sort	promoter polymorphism -857с>t of tnfα gene and efficacy of anticytokine therapy in patients with rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/95b6b45dc0704e0f90fa95372ca01f96
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PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS

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