MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus

BACKGROUND: Damage of arterial walls in diabetes mellitus associated with arterial hypertension is major factor delivering lesion of target organs. Currently, enough data is not available about imaging and quantitative evaluations of arterial wall. There is no enough data available about the relatio...

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Autores principales:	Nadezhda I. Ryumshina, Alla Y. Falkovskaya, Anna M. Gusakova, Victor F. Mordovin, Vladimir Y. Usov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2020
Materias:	magnetic-resonance imaging with contrast enhancement diabetes mellitus resistant arterial hypertension vessels wall inflammation Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/95ba75d5d8c840acb8befb44215ed69c
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spelling	oai:doaj.org-article:95ba75d5d8c840acb8befb44215ed69c2021-11-14T09:00:22ZMRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus2072-03512072-037810.14341/DM10169https://doaj.org/article/95ba75d5d8c840acb8befb44215ed69c2020-04-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10169https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: Damage of arterial walls in diabetes mellitus associated with arterial hypertension is major factor delivering lesion of target organs. Currently, enough data is not available about imaging and quantitative evaluations of arterial wall. There is no enough data available about the relations between MRI and inflammatory and metabolic markers in patients with resistant arterial hypertension concomitant with diabetes mellitus. AIMS: Quantitative assessment of the intensity of paramagnetic contrast enhancement of the arterial wall, in particular renal arteries walls, in relation with inflammatory and metabolic markers in patients with resistant arterial hypertension concomitant with diabetes mellitus. MATERIALS AND METHODS: The study groups were comprised of 28 patients (ageing 60,7±6,5 years) with resistant hypertension accompanied with diabetes mellitus and 17 patients (aging 57,7±5,0 years) with resistant hypertension without diabetes mellitus. The average systolic/diastolic pressure obtained from a 24-h monitor study was as high as 156,8±16,9/81,9,0±13,5 mm Hg in the group with diabetes and 154,8±11,9/88,5±10,4 mm Hg in the group without diabetes. The values of glycaemia, the level of glycated haemoglobin, and C-reactive protein were determined. The MRI studies were carried out using 1,5 Т MRI Toshiba Vantage Titan scanner. After that, the intravenous contrast enhancement has been carried out (with 0,5 М paramagnetic, as 0,2 ml/Kg). The index of enhancement (IE) was then calculated from these data, as a ratio of intensities of contrast-enhanced image to the initial nonenhanced MRI scan. RESULTS: The correlation was obtained for IE of arterial wall and data of blood pressure. Increased IE was correlated with ageing and hemodynamic factors. Also the correlation was observed for IE proximal, medium and distal parts of renal arteries and values of glycaemia and NOMA-index were obtained. Negatively correlated values for IE and adiponectin in the group with diabetes mellitus were obtained. The association between IE and C-reactive protein remained significant in the group without diabetes mellitus. CONCLUSIONS: MRI with contrast enhancement of arterial walls allows evaluating the anatomy of renal arteries and allows quantifying the pathophysiologic factors of their walls in patients with resistant hypertension accompanied with diabetes mellitus. MRI characteristics of the arterial wall were associated not only with hemodynamic and metabolic data, but also with markers of inflammation.Nadezhda I. RyumshinaAlla Y. FalkovskayaAnna M. GusakovaVictor F. MordovinVladimir Y. UsovEndocrinology Research Centrearticlemagnetic-resonance imaging with contrast enhancementdiabetes mellitusresistant arterial hypertensionvessels wall inflammationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 1, Pp 29-36 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	magnetic-resonance imaging with contrast enhancement diabetes mellitus resistant arterial hypertension vessels wall inflammation Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	magnetic-resonance imaging with contrast enhancement diabetes mellitus resistant arterial hypertension vessels wall inflammation Nutritional diseases. Deficiency diseases RC620-627 Nadezhda I. Ryumshina Alla Y. Falkovskaya Anna M. Gusakova Victor F. Mordovin Vladimir Y. Usov MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
description	BACKGROUND: Damage of arterial walls in diabetes mellitus associated with arterial hypertension is major factor delivering lesion of target organs. Currently, enough data is not available about imaging and quantitative evaluations of arterial wall. There is no enough data available about the relations between MRI and inflammatory and metabolic markers in patients with resistant arterial hypertension concomitant with diabetes mellitus. AIMS: Quantitative assessment of the intensity of paramagnetic contrast enhancement of the arterial wall, in particular renal arteries walls, in relation with inflammatory and metabolic markers in patients with resistant arterial hypertension concomitant with diabetes mellitus. MATERIALS AND METHODS: The study groups were comprised of 28 patients (ageing 60,7±6,5 years) with resistant hypertension accompanied with diabetes mellitus and 17 patients (aging 57,7±5,0 years) with resistant hypertension without diabetes mellitus. The average systolic/diastolic pressure obtained from a 24-h monitor study was as high as 156,8±16,9/81,9,0±13,5 mm Hg in the group with diabetes and 154,8±11,9/88,5±10,4 mm Hg in the group without diabetes. The values of glycaemia, the level of glycated haemoglobin, and C-reactive protein were determined. The MRI studies were carried out using 1,5 Т MRI Toshiba Vantage Titan scanner. After that, the intravenous contrast enhancement has been carried out (with 0,5 М paramagnetic, as 0,2 ml/Kg). The index of enhancement (IE) was then calculated from these data, as a ratio of intensities of contrast-enhanced image to the initial nonenhanced MRI scan. RESULTS: The correlation was obtained for IE of arterial wall and data of blood pressure. Increased IE was correlated with ageing and hemodynamic factors. Also the correlation was observed for IE proximal, medium and distal parts of renal arteries and values of glycaemia and NOMA-index were obtained. Negatively correlated values for IE and adiponectin in the group with diabetes mellitus were obtained. The association between IE and C-reactive protein remained significant in the group without diabetes mellitus. CONCLUSIONS: MRI with contrast enhancement of arterial walls allows evaluating the anatomy of renal arteries and allows quantifying the pathophysiologic factors of their walls in patients with resistant hypertension accompanied with diabetes mellitus. MRI characteristics of the arterial wall were associated not only with hemodynamic and metabolic data, but also with markers of inflammation.
format	article
author	Nadezhda I. Ryumshina Alla Y. Falkovskaya Anna M. Gusakova Victor F. Mordovin Vladimir Y. Usov
author_facet	Nadezhda I. Ryumshina Alla Y. Falkovskaya Anna M. Gusakova Victor F. Mordovin Vladimir Y. Usov
author_sort	Nadezhda I. Ryumshina
title	MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
title_short	MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
title_full	MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
title_fullStr	MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
title_full_unstemmed	MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
title_sort	mri of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2020
url	https://doaj.org/article/95ba75d5d8c840acb8befb44215ed69c
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MRI of the arterial wall in resistant hypertension associated with type 2 diabetes mellitus

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