Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.

<h4>Background</h4>Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To...

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Autores principales:	Clifford Liongue, Lynda A O'Sullivan, Monique C Trengove, Alister C Ward
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/95bb0633bf5e47cca844c3fec3a56a3c
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spelling	oai:doaj.org-article:95bb0633bf5e47cca844c3fec3a56a3c2021-11-18T07:25:50ZEvolution of JAK-STAT pathway components: mechanisms and role in immune system development.1932-620310.1371/journal.pone.0032777https://doaj.org/article/95bb0633bf5e47cca844c3fec3a56a3c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412924/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To gain further insight into immune system evolution, we have performed a comprehensive bioinformatic analysis of the JAK-STAT pathway components, including the key negative regulators of this pathway, the SH2-domain containing tyrosine phosphatase (SHP), Protein inhibitors against Stats (PIAS), and Suppressor of cytokine signaling (SOCS) proteins across a diverse range of organisms.<h4>Results</h4>Our analysis has demonstrated significant expansion of JAK-STAT pathway components co-incident with the emergence of adaptive immunity, with whole genome duplication being the principal mechanism for generating this additional diversity. In contrast, expansion of upstream cytokine receptors appears to be a pivotal driver for the differential diversification of specific pathway components.<h4>Conclusion</h4>Diversification of JAK-STAT pathway components during early vertebrate development occurred concurrently with a major expansion of upstream cytokine receptors and two rounds of whole genome duplications. This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity.Clifford LiongueLynda A O'SullivanMonique C TrengoveAlister C WardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32777 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clifford Liongue Lynda A O'Sullivan Monique C Trengove Alister C Ward Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.
description	<h4>Background</h4>Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To gain further insight into immune system evolution, we have performed a comprehensive bioinformatic analysis of the JAK-STAT pathway components, including the key negative regulators of this pathway, the SH2-domain containing tyrosine phosphatase (SHP), Protein inhibitors against Stats (PIAS), and Suppressor of cytokine signaling (SOCS) proteins across a diverse range of organisms.<h4>Results</h4>Our analysis has demonstrated significant expansion of JAK-STAT pathway components co-incident with the emergence of adaptive immunity, with whole genome duplication being the principal mechanism for generating this additional diversity. In contrast, expansion of upstream cytokine receptors appears to be a pivotal driver for the differential diversification of specific pathway components.<h4>Conclusion</h4>Diversification of JAK-STAT pathway components during early vertebrate development occurred concurrently with a major expansion of upstream cytokine receptors and two rounds of whole genome duplications. This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity.
format	article
author	Clifford Liongue Lynda A O'Sullivan Monique C Trengove Alister C Ward
author_facet	Clifford Liongue Lynda A O'Sullivan Monique C Trengove Alister C Ward
author_sort	Clifford Liongue
title	Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.
title_short	Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.
title_full	Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.
title_fullStr	Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.
title_full_unstemmed	Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.
title_sort	evolution of jak-stat pathway components: mechanisms and role in immune system development.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/95bb0633bf5e47cca844c3fec3a56a3c
work_keys_str_mv	AT cliffordliongue evolutionofjakstatpathwaycomponentsmechanismsandroleinimmunesystemdevelopment AT lyndaaosullivan evolutionofjakstatpathwaycomponentsmechanismsandroleinimmunesystemdevelopment AT moniquectrengove evolutionofjakstatpathwaycomponentsmechanismsandroleinimmunesystemdevelopment AT alistercward evolutionofjakstatpathwaycomponentsmechanismsandroleinimmunesystemdevelopment
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Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.

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