Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.

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Autores principales:	Chia-Wei Li, Seung-Oe Lim, Weiya Xia, Heng-Huan Lee, Li-Chuan Chan, Chu-Wei Kuo, Kay-Hooi Khoo, Shih-Shin Chang, Jong-Ho Cha, Taewan Kim, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Qingqing Ding, Yan Wang, Jun Yao, Cheng-Chung Lee, Hsing-Ju Wu, Aysegul A. Sahin, James P. Allison, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95bbbbb825d74f9a9d75ce9718db0cfa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:95bbbbb825d74f9a9d75ce9718db0cfa2021-12-02T17:31:48ZGlycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity10.1038/ncomms126322041-1723https://doaj.org/article/95bbbbb825d74f9a9d75ce9718db0cfa2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12632https://doaj.org/toc/2041-1723Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.Chia-Wei LiSeung-Oe LimWeiya XiaHeng-Huan LeeLi-Chuan ChanChu-Wei KuoKay-Hooi KhooShih-Shin ChangJong-Ho ChaTaewan KimJennifer L. HsuYun WuJung-Mao HsuHirohito YamaguchiQingqing DingYan WangJun YaoCheng-Chung LeeHsing-Ju WuAysegul A. SahinJames P. AllisonDihua YuGabriel N. HortobagyiMien-Chie HungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
description	Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.
format	article
author	Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung
author_facet	Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung
author_sort	Chia-Wei Li
title	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_short	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_full	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_fullStr	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_full_unstemmed	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_sort	glycosylation and stabilization of programmed death ligand-1 suppresses t-cell activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/95bbbbb825d74f9a9d75ce9718db0cfa
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Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

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