LC–MS based case-by-case analysis of the impact of acidic and basic charge variants of bevacizumab on stability and biological activity
Abstract The present study investigates the impact of charge variants on bevacizumab's structure, stability, and biological activity. Five basic and one acidic charge variants were separated using semi-preparative cation exchange chromatography using linear pH gradient elution with purity > ...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/95c2af03819a449dadb3673598c9d62f |
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