A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells

Abstract Lymphocyte cytosolic protein 2 (LCP2) is one of the SLP-76 family of adapters, which are critical intermediates in signal cascades downstream of several receptors. LCP2 regulates immunoreceptor signaling (such as T-cell receptors) and is also required for integrin signaling in neutrophils a...

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Autores principales:	Zijun Wang, Mou Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/95c560665d134e6397edd17fead5bf09
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spelling	oai:doaj.org-article:95c560665d134e6397edd17fead5bf092021-12-02T16:56:10ZA novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells10.1038/s41598-021-88676-92045-2322https://doaj.org/article/95c560665d134e6397edd17fead5bf092021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88676-9https://doaj.org/toc/2045-2322Abstract Lymphocyte cytosolic protein 2 (LCP2) is one of the SLP-76 family of adapters, which are critical intermediates in signal cascades downstream of several receptors. LCP2 regulates immunoreceptor signaling (such as T-cell receptors) and is also required for integrin signaling in neutrophils and platelets. However, the role of LCP2 in the tumor microenvironment is still unknown. In this study, we found a significant increase of mRNA and protein expression of LCP2 in metastatic skin cutaneous melanoma compared to normal skin. The upregulation of LCP2 was associated with good overall survival of patients with metastatic skin cutaneous melanoma, who received pharmacotherapy and radiation. GSEA signaling pathways analysis showed that LCP2 was involved in multiple pathways of immune response and correlation analysis revealed LCP2 was positively correlated with molecules in TCR signaling and 11 immune checkpoints, while LCP2 negatively correlated with 2 immune checkpoints in the metastatic skin cutaneous melanoma. According to the different expressions of LCP2, high LCP2 expression was positively correlated with more tumor-infiltrating CD8+ T cells. Furthermore, Kaplan–Meier plot indicated that LCP2 acted as a prognostic biomarker for progression-free survival of patients with metastatic skin cutaneous melanoma receiving anti-PD1 immunotherapy. In conclusion, our results integrated both the expression and function of LCP2 in melanoma using multiple tools, shedding light on the potential role of LCP2 in melanoma, and suggesting LCP2 serves as a prognostic biomarker and therapeutic target in anti-tumor immunity.Zijun WangMou PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zijun Wang Mou Peng A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells
description	Abstract Lymphocyte cytosolic protein 2 (LCP2) is one of the SLP-76 family of adapters, which are critical intermediates in signal cascades downstream of several receptors. LCP2 regulates immunoreceptor signaling (such as T-cell receptors) and is also required for integrin signaling in neutrophils and platelets. However, the role of LCP2 in the tumor microenvironment is still unknown. In this study, we found a significant increase of mRNA and protein expression of LCP2 in metastatic skin cutaneous melanoma compared to normal skin. The upregulation of LCP2 was associated with good overall survival of patients with metastatic skin cutaneous melanoma, who received pharmacotherapy and radiation. GSEA signaling pathways analysis showed that LCP2 was involved in multiple pathways of immune response and correlation analysis revealed LCP2 was positively correlated with molecules in TCR signaling and 11 immune checkpoints, while LCP2 negatively correlated with 2 immune checkpoints in the metastatic skin cutaneous melanoma. According to the different expressions of LCP2, high LCP2 expression was positively correlated with more tumor-infiltrating CD8+ T cells. Furthermore, Kaplan–Meier plot indicated that LCP2 acted as a prognostic biomarker for progression-free survival of patients with metastatic skin cutaneous melanoma receiving anti-PD1 immunotherapy. In conclusion, our results integrated both the expression and function of LCP2 in melanoma using multiple tools, shedding light on the potential role of LCP2 in melanoma, and suggesting LCP2 serves as a prognostic biomarker and therapeutic target in anti-tumor immunity.
format	article
author	Zijun Wang Mou Peng
author_facet	Zijun Wang Mou Peng
author_sort	Zijun Wang
title	A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells
title_short	A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells
title_full	A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells
title_fullStr	A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells
title_full_unstemmed	A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells
title_sort	novel prognostic biomarker lcp2 correlates with metastatic melanoma-infiltrating cd8+ t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95c560665d134e6397edd17fead5bf09
work_keys_str_mv	AT zijunwang anovelprognosticbiomarkerlcp2correlateswithmetastaticmelanomainfiltratingcd8tcells AT moupeng anovelprognosticbiomarkerlcp2correlateswithmetastaticmelanomainfiltratingcd8tcells AT zijunwang novelprognosticbiomarkerlcp2correlateswithmetastaticmelanomainfiltratingcd8tcells AT moupeng novelprognosticbiomarkerlcp2correlateswithmetastaticmelanomainfiltratingcd8tcells
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A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells

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