Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents

ObjectiveThis study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents.MethodsA total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhu...

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Autores principales:	Yang Niu, Qingya Tang, Xuan Zhao, Xuelin Zhao, Xiaomeng Mao, Jinye Sheng, Wei Cai, Yi Feng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	insulin resistance uric acid obesity children adolescents Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/95c60e56189b4ed8aad5e5ffd88f2ca8
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spelling	oai:doaj.org-article:95c60e56189b4ed8aad5e5ffd88f2ca82021-12-03T09:57:18ZObesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents1664-239210.3389/fendo.2021.773820https://doaj.org/article/95c60e56189b4ed8aad5e5ffd88f2ca82021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.773820/fullhttps://doaj.org/toc/1664-2392ObjectiveThis study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents.MethodsA total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 to January 2019 were recruited for this retrospective study. We classified participants into two groups on the basis of HOMA-IR values: the low HOMA-IR group (< 3.16) (n = 222) and the high HOMA-IR group (≥ 3.16) (n = 147).ResultsThe univariate analysis found that the high HOMA-IR group had higher BMI, SUA, and fasting insulin (FINS) (P < 0.05). Multiple linear regression analysis and mediating effect analysis indicated that body mass index (BMI) could directly regulate FINS and HOMA-IR (both P < 0.05). The results from the mediating effect analysis found that UA partially played an indirect role in the link between BMI, FINS and HOMA-IR (both P < 0.05) but had no effect on fasting blood glucose (P > 0.05).ConclusionsSUA should be investigated in obesity and plays a partial mediating role in insulin resistance induced by obesity in obese children and adolescents.Yang NiuQingya TangQingya TangXuan ZhaoXuelin ZhaoXiaomeng MaoJinye ShengWei CaiWei CaiWei CaiYi FengFrontiers Media S.A.articleinsulin resistanceuric acidobesitychildrenadolescentsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin resistance uric acid obesity children adolescents Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	insulin resistance uric acid obesity children adolescents Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yang Niu Qingya Tang Qingya Tang Xuan Zhao Xuelin Zhao Xiaomeng Mao Jinye Sheng Wei Cai Wei Cai Wei Cai Yi Feng Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
description	ObjectiveThis study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents.MethodsA total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 to January 2019 were recruited for this retrospective study. We classified participants into two groups on the basis of HOMA-IR values: the low HOMA-IR group (< 3.16) (n = 222) and the high HOMA-IR group (≥ 3.16) (n = 147).ResultsThe univariate analysis found that the high HOMA-IR group had higher BMI, SUA, and fasting insulin (FINS) (P < 0.05). Multiple linear regression analysis and mediating effect analysis indicated that body mass index (BMI) could directly regulate FINS and HOMA-IR (both P < 0.05). The results from the mediating effect analysis found that UA partially played an indirect role in the link between BMI, FINS and HOMA-IR (both P < 0.05) but had no effect on fasting blood glucose (P > 0.05).ConclusionsSUA should be investigated in obesity and plays a partial mediating role in insulin resistance induced by obesity in obese children and adolescents.
format	article
author	Yang Niu Qingya Tang Qingya Tang Xuan Zhao Xuelin Zhao Xiaomeng Mao Jinye Sheng Wei Cai Wei Cai Wei Cai Yi Feng
author_facet	Yang Niu Qingya Tang Qingya Tang Xuan Zhao Xuelin Zhao Xiaomeng Mao Jinye Sheng Wei Cai Wei Cai Wei Cai Yi Feng
author_sort	Yang Niu
title	Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
title_short	Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
title_full	Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
title_fullStr	Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
title_full_unstemmed	Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
title_sort	obesity-induced insulin resistance is mediated by high uric acid in obese children and adolescents
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/95c60e56189b4ed8aad5e5ffd88f2ca8
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Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents

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