Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
Xin Jin,1,2 Xinyue Lu,3 Zhenhai Zhang,4 Huixia Lv3 1Department of Hospital Pharmacy, Suqian First Hospital, Suqian 223800, People’s Republic of China; 2Department of Pharmaceutics, Suqian Clinical College of Xuzhou Medical University, Suqian 223800, People’s Republic of China; 3D...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2020
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| Acceso en línea: | https://doaj.org/article/95cd896895724639b5db0d7c585a8163 |
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| Sumario: | Xin Jin,1,2 Xinyue Lu,3 Zhenhai Zhang,4 Huixia Lv3 1Department of Hospital Pharmacy, Suqian First Hospital, Suqian 223800, People’s Republic of China; 2Department of Pharmaceutics, Suqian Clinical College of Xuzhou Medical University, Suqian 223800, People’s Republic of China; 3Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, People’s Republic of China; 4Jiangsu Province Hospital on Integration of Chinese and Western Medicine Affiliated with Nanjing University of Chinese Medicine, Nanjing 210000, People’s Republic of ChinaCorrespondence: Zhenhai Zhang; Huixia Lv Tel +8618913823932; +8613912965842Email david23932@163.com; lvhuixia@163.comBackground: Certain patients with triple-negative breast cancer cannot tolerate the serious adverse effects of cytotoxic chemotherapy agents, which significantly affect the disease prognosis.Purpose: Research into the combined use of photosensitizers and non-cytotoxic antineoplastic drugs for the safe treatment of triple-negative breast cancer is vital.Methods: In this study, the photosensitizer indocyanine green and the natural drug parthenolide were co-loaded into thermosensitive liposomes. Under a near-infrared irradiation, indocyanine green reached excitation levels, releasing heat, and the liposome underwent a phase transition, releasing the drug were researched.Results: Thus, indocyanine green and parthenolide exert synergistic antineoplastic effects. In the nude mice xenograft MDA-MB-231 tumor model, the tumor inhibition rate of indocyanine green-parthenolide thermosensitive liposomes was approximately 2.08-fold than that of paclitaxel and demonstrated a good initial safety evaluation.Conclusion: Photosensitizers and non-cytotoxic antineoplastic agents in combination with nanoscale carriers should be further investigated for the treatment of tumors.Keywords: indocyanine green, parthenolide, thermosensitive liposomes, triple-negative breast cancer, chemo-photothermal synergetic therapy |
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