Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer

Xin Jin,1,2 Xinyue Lu,3 Zhenhai Zhang,4 Huixia Lv3 1Department of Hospital Pharmacy, Suqian First Hospital, Suqian 223800, People’s Republic of China; 2Department of Pharmaceutics, Suqian Clinical College of Xuzhou Medical University, Suqian 223800, People’s Republic of China; 3D...

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Autores principales:	Jin X, Lu X, Zhang Z, Lv H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	indocyanine green parthenolide thermosensitive liposomes triple-negative breast cancer chemo-photothermal synergetic therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/95cd896895724639b5db0d7c585a8163
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spelling	oai:doaj.org-article:95cd896895724639b5db0d7c585a81632021-12-02T08:36:19ZIndocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer1178-2013https://doaj.org/article/95cd896895724639b5db0d7c585a81632020-05-01T00:00:00Zhttps://www.dovepress.com/indocyanine-green-parthenolide-thermosensitive-liposome-combination-tr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xin Jin,1,2 Xinyue Lu,3 Zhenhai Zhang,4 Huixia Lv3 1Department of Hospital Pharmacy, Suqian First Hospital, Suqian 223800, People’s Republic of China; 2Department of Pharmaceutics, Suqian Clinical College of Xuzhou Medical University, Suqian 223800, People’s Republic of China; 3Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, People’s Republic of China; 4Jiangsu Province Hospital on Integration of Chinese and Western Medicine Affiliated with Nanjing University of Chinese Medicine, Nanjing 210000, People’s Republic of ChinaCorrespondence: Zhenhai Zhang; Huixia Lv Tel +8618913823932; +8613912965842Email david23932@163.com; lvhuixia@163.comBackground: Certain patients with triple-negative breast cancer cannot tolerate the serious adverse effects of cytotoxic chemotherapy agents, which significantly affect the disease prognosis.Purpose: Research into the combined use of photosensitizers and non-cytotoxic antineoplastic drugs for the safe treatment of triple-negative breast cancer is vital.Methods: In this study, the photosensitizer indocyanine green and the natural drug parthenolide were co-loaded into thermosensitive liposomes. Under a near-infrared irradiation, indocyanine green reached excitation levels, releasing heat, and the liposome underwent a phase transition, releasing the drug were researched.Results: Thus, indocyanine green and parthenolide exert synergistic antineoplastic effects. In the nude mice xenograft MDA-MB-231 tumor model, the tumor inhibition rate of indocyanine green-parthenolide thermosensitive liposomes was approximately 2.08-fold than that of paclitaxel and demonstrated a good initial safety evaluation.Conclusion: Photosensitizers and non-cytotoxic antineoplastic agents in combination with nanoscale carriers should be further investigated for the treatment of tumors.Keywords: indocyanine green, parthenolide, thermosensitive liposomes, triple-negative breast cancer, chemo-photothermal synergetic therapyJin XLu XZhang ZLv HDove Medical Pressarticleindocyanine greenparthenolidethermosensitive liposomestriple-negative breast cancerchemo-photothermal synergetic therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3193-3206 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	indocyanine green parthenolide thermosensitive liposomes triple-negative breast cancer chemo-photothermal synergetic therapy Medicine (General) R5-920
spellingShingle	indocyanine green parthenolide thermosensitive liposomes triple-negative breast cancer chemo-photothermal synergetic therapy Medicine (General) R5-920 Jin X Lu X Zhang Z Lv H Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
description	Xin Jin,1,2 Xinyue Lu,3 Zhenhai Zhang,4 Huixia Lv3 1Department of Hospital Pharmacy, Suqian First Hospital, Suqian 223800, People’s Republic of China; 2Department of Pharmaceutics, Suqian Clinical College of Xuzhou Medical University, Suqian 223800, People’s Republic of China; 3Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, People’s Republic of China; 4Jiangsu Province Hospital on Integration of Chinese and Western Medicine Affiliated with Nanjing University of Chinese Medicine, Nanjing 210000, People’s Republic of ChinaCorrespondence: Zhenhai Zhang; Huixia Lv Tel +8618913823932; +8613912965842Email david23932@163.com; lvhuixia@163.comBackground: Certain patients with triple-negative breast cancer cannot tolerate the serious adverse effects of cytotoxic chemotherapy agents, which significantly affect the disease prognosis.Purpose: Research into the combined use of photosensitizers and non-cytotoxic antineoplastic drugs for the safe treatment of triple-negative breast cancer is vital.Methods: In this study, the photosensitizer indocyanine green and the natural drug parthenolide were co-loaded into thermosensitive liposomes. Under a near-infrared irradiation, indocyanine green reached excitation levels, releasing heat, and the liposome underwent a phase transition, releasing the drug were researched.Results: Thus, indocyanine green and parthenolide exert synergistic antineoplastic effects. In the nude mice xenograft MDA-MB-231 tumor model, the tumor inhibition rate of indocyanine green-parthenolide thermosensitive liposomes was approximately 2.08-fold than that of paclitaxel and demonstrated a good initial safety evaluation.Conclusion: Photosensitizers and non-cytotoxic antineoplastic agents in combination with nanoscale carriers should be further investigated for the treatment of tumors.Keywords: indocyanine green, parthenolide, thermosensitive liposomes, triple-negative breast cancer, chemo-photothermal synergetic therapy
format	article
author	Jin X Lu X Zhang Z Lv H
author_facet	Jin X Lu X Zhang Z Lv H
author_sort	Jin X
title	Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
title_short	Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
title_full	Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
title_fullStr	Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
title_full_unstemmed	Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer
title_sort	indocyanine green-parthenolide thermosensitive liposome combination treatment for triple-negative breast cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/95cd896895724639b5db0d7c585a8163
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Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer

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