Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE

Objectives: Macroprolactin (macroPRL) excess is an important cause of hyperprolactinemia. Several prolactin assays have high reactivity to macroPRL. However, macroPRL screening is not routinely performed in many labs. This study aimed to evaluate the prevalence of macroprolactinemia (MP) in patients...

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Autores principales:	Abdulla Al Nuaimi, Raya Almazrouei, Yusra Othman, Salem Beshyah, Khaled M. Aldahmani
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	hyperprolactinemia macroprolactin pituitary Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/95ce0acd1b564f3fba92a5e860cd035c
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spelling	oai:doaj.org-article:95ce0acd1b564f3fba92a5e860cd035c2021-11-25T07:47:21ZPrevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE2673-17972673-173810.1159/000519094https://doaj.org/article/95ce0acd1b564f3fba92a5e860cd035c2021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519094https://doaj.org/toc/2673-1797https://doaj.org/toc/2673-1738Objectives: Macroprolactin (macroPRL) excess is an important cause of hyperprolactinemia. Several prolactin assays have high reactivity to macroPRL. However, macroPRL screening is not routinely performed in many labs. This study aimed to evaluate the prevalence of macroprolactinemia (MP) in patients with elevated prolactin using the Roche Elecsys assay in a large tertiary center in UAE. Materials and Methods: Consecutive samples of patients with elevated prolactin presenting to Tawam Hospital from June to August 2018 were evaluated for MP. Polyethylene glycol (PEG) was used to precipitate macroPRL. Monomeric prolactin recovery cutoff ≤50% was used to determine the prevalence of MP. Results: A total of 180 patients with elevated prolactin were included in the study with a mean age of 33.1 ± 11.9 years. The majority were women (87.2%), and about 77.8% were newly diagnosed patients with hyperprolactinemia. The main indications for prolactin testing were menstrual irregularity (n = 121), infertility (n = 11), galactorrhea (n = 11), and sellar masses (n = 12). MP was present in 8.3% of the patients. The median (IQR) of total prolactin level was 740.5 (579–1,085) IU/m before PEG precipitation and was not significantly different between MP and true hyperprolactinemia cases. Three patients with MP had pituitary MRI evaluation, which was normal. Eight patients with MP were treated with cabergoline. Conclusion: One in 12 patients with hyperprolactinemia had MP on the Roche Elecsys assay defined as the cutoff recovery of ≤50% post-PEG precipitation. Physicians should be aware of the prolactin assay used in their labs, and we recommend routine macroPRL assessment in mild hyperprolactinemia samples in labs using the Roche Elecsys platform.Abdulla Al NuaimiRaya AlmazroueiYusra OthmanSalem BeshyahKhaled M. AldahmaniKarger PublishersarticlehyperprolactinemiamacroprolactinpituitaryDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENDubai Diabetes and Endocrinology Journal, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperprolactinemia macroprolactin pituitary Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	hyperprolactinemia macroprolactin pituitary Diseases of the endocrine glands. Clinical endocrinology RC648-665 Abdulla Al Nuaimi Raya Almazrouei Yusra Othman Salem Beshyah Khaled M. Aldahmani Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE
description	Objectives: Macroprolactin (macroPRL) excess is an important cause of hyperprolactinemia. Several prolactin assays have high reactivity to macroPRL. However, macroPRL screening is not routinely performed in many labs. This study aimed to evaluate the prevalence of macroprolactinemia (MP) in patients with elevated prolactin using the Roche Elecsys assay in a large tertiary center in UAE. Materials and Methods: Consecutive samples of patients with elevated prolactin presenting to Tawam Hospital from June to August 2018 were evaluated for MP. Polyethylene glycol (PEG) was used to precipitate macroPRL. Monomeric prolactin recovery cutoff ≤50% was used to determine the prevalence of MP. Results: A total of 180 patients with elevated prolactin were included in the study with a mean age of 33.1 ± 11.9 years. The majority were women (87.2%), and about 77.8% were newly diagnosed patients with hyperprolactinemia. The main indications for prolactin testing were menstrual irregularity (n = 121), infertility (n = 11), galactorrhea (n = 11), and sellar masses (n = 12). MP was present in 8.3% of the patients. The median (IQR) of total prolactin level was 740.5 (579–1,085) IU/m before PEG precipitation and was not significantly different between MP and true hyperprolactinemia cases. Three patients with MP had pituitary MRI evaluation, which was normal. Eight patients with MP were treated with cabergoline. Conclusion: One in 12 patients with hyperprolactinemia had MP on the Roche Elecsys assay defined as the cutoff recovery of ≤50% post-PEG precipitation. Physicians should be aware of the prolactin assay used in their labs, and we recommend routine macroPRL assessment in mild hyperprolactinemia samples in labs using the Roche Elecsys platform.
format	article
author	Abdulla Al Nuaimi Raya Almazrouei Yusra Othman Salem Beshyah Khaled M. Aldahmani
author_facet	Abdulla Al Nuaimi Raya Almazrouei Yusra Othman Salem Beshyah Khaled M. Aldahmani
author_sort	Abdulla Al Nuaimi
title	Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE
title_short	Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE
title_full	Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE
title_fullStr	Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE
title_full_unstemmed	Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE
title_sort	prevalence of macroprolactinemia in patients with hyperprolactinemia using roche elecsys platform in a large tertiary referral center in uae
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/95ce0acd1b564f3fba92a5e860cd035c
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Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE

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