Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype

Multiple sclerosis (MS), a neuroinflammatory disorder, occurs as non-progressive or progressive phenotypes; both forms present with diverse symptoms that may reduce quality of life (QoL). Adherence to healthy lifestyle behaviors has been associated with higher QoL in people with MS; whether these as...

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Autores principales:	Nupur Nag, Maggie Yu, George A. Jelinek, Steve Simpson-Yap, Sandra L. Neate, Hollie K. Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple sclerosis lifestyle behavior MS management MS phenotype quality of life Medicine R
Acceso en línea:	https://doaj.org/article/95ce6e1f48134b3fa53181033f68cb53
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spelling	oai:doaj.org-article:95ce6e1f48134b3fa53181033f68cb532021-11-25T18:08:06ZAssociations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype10.3390/jpm111112182075-4426https://doaj.org/article/95ce6e1f48134b3fa53181033f68cb532021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1218https://doaj.org/toc/2075-4426Multiple sclerosis (MS), a neuroinflammatory disorder, occurs as non-progressive or progressive phenotypes; both forms present with diverse symptoms that may reduce quality of life (QoL). Adherence to healthy lifestyle behaviors has been associated with higher QoL in people with MS; whether these associations differ based on MS phenotype is unknown. Cross-sectional self-reported observational data from 1108 iConquerMS participants were analysed. Associations between lifestyle behaviors and QoL were assessed by linear regression, and phenotype differences via moderation analyses. Diet, wellness, and physical activity, but not vitamin D or omega-3 supplement use, were associated with QoL. Specifically, certain diet types were negatively associated with QoL in relapsing-remitting MS (RRMS), and positively associated in progressive MS (ProgMS). Participation in wellness activities had mixed associations with QoL in RRMS but was not associated in ProgMS. Physical activity was positively associated with QoL in RRMS and ProgMS. Phenotype differences were observed in diet and wellness with physical QoL, and physical activity with most QoL subdomains. Our findings show lifestyle behaviors are associated with QoL and appear to differ based on MS phenotype. Future studies assessing timing, duration, and adherence of adopting lifestyle behaviors may better inform their role in MS management.Nupur NagMaggie YuGeorge A. JelinekSteve Simpson-YapSandra L. NeateHollie K. SchmidtMDPI AGarticlemultiple sclerosislifestyle behaviorMS managementMS phenotypequality of lifeMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1218, p 1218 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis lifestyle behavior MS management MS phenotype quality of life Medicine R
spellingShingle	multiple sclerosis lifestyle behavior MS management MS phenotype quality of life Medicine R Nupur Nag Maggie Yu George A. Jelinek Steve Simpson-Yap Sandra L. Neate Hollie K. Schmidt Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
description	Multiple sclerosis (MS), a neuroinflammatory disorder, occurs as non-progressive or progressive phenotypes; both forms present with diverse symptoms that may reduce quality of life (QoL). Adherence to healthy lifestyle behaviors has been associated with higher QoL in people with MS; whether these associations differ based on MS phenotype is unknown. Cross-sectional self-reported observational data from 1108 iConquerMS participants were analysed. Associations between lifestyle behaviors and QoL were assessed by linear regression, and phenotype differences via moderation analyses. Diet, wellness, and physical activity, but not vitamin D or omega-3 supplement use, were associated with QoL. Specifically, certain diet types were negatively associated with QoL in relapsing-remitting MS (RRMS), and positively associated in progressive MS (ProgMS). Participation in wellness activities had mixed associations with QoL in RRMS but was not associated in ProgMS. Physical activity was positively associated with QoL in RRMS and ProgMS. Phenotype differences were observed in diet and wellness with physical QoL, and physical activity with most QoL subdomains. Our findings show lifestyle behaviors are associated with QoL and appear to differ based on MS phenotype. Future studies assessing timing, duration, and adherence of adopting lifestyle behaviors may better inform their role in MS management.
format	article
author	Nupur Nag Maggie Yu George A. Jelinek Steve Simpson-Yap Sandra L. Neate Hollie K. Schmidt
author_facet	Nupur Nag Maggie Yu George A. Jelinek Steve Simpson-Yap Sandra L. Neate Hollie K. Schmidt
author_sort	Nupur Nag
title	Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
title_short	Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
title_full	Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
title_fullStr	Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
title_full_unstemmed	Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype
title_sort	associations between lifestyle behaviors and quality of life differ based on multiple sclerosis phenotype
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/95ce6e1f48134b3fa53181033f68cb53
work_keys_str_mv	AT nupurnag associationsbetweenlifestylebehaviorsandqualityoflifedifferbasedonmultiplesclerosisphenotype AT maggieyu associationsbetweenlifestylebehaviorsandqualityoflifedifferbasedonmultiplesclerosisphenotype AT georgeajelinek associationsbetweenlifestylebehaviorsandqualityoflifedifferbasedonmultiplesclerosisphenotype AT stevesimpsonyap associationsbetweenlifestylebehaviorsandqualityoflifedifferbasedonmultiplesclerosisphenotype AT sandralneate associationsbetweenlifestylebehaviorsandqualityoflifedifferbasedonmultiplesclerosisphenotype AT holliekschmidt associationsbetweenlifestylebehaviorsandqualityoflifedifferbasedonmultiplesclerosisphenotype
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Associations between Lifestyle Behaviors and Quality of Life Differ Based on Multiple Sclerosis Phenotype

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