Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems

Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems

Abstract Advanced glycation endproducts (AGEs) are involved in several diseases, including NAFLD and NASH. RAGE is the main receptor mediating the pro-inflammatory signalling induced by AGEs. Therefore, targeting of RAGE has been proposed for prevention of chronic inflammatory diseases. However, the...

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Main Authors: Kristiaan Wouters, Alessia S. Cento, Katrien H. Gaens, Margee Teunissen, Jean L. J. M. Scheijen, Federica Barutta, Fausto Chiazza, Debora Collotta, Manuela Aragno, Gabriella Gruden, Massimo Collino, Casper G. Schalkwijk, Raffaella Mastrocola
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/95cedba2ffd84ffbafb3eae79144aabe
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https://doaj.org/article/95cedba2ffd84ffbafb3eae79144aabe

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