Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection

Abstract Curative resection is recommended for patient with early stage hepatocellular carcinoma (HCC), however, the prognosis is limited by high recurrence rate. This study was to investigate liver stiffness (LS) and metabolic factor in prediction of HCC recurrence for patients with early stage HCC...

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Autores principales:	Jing-Houng Wang, Wei-Feng Li, Chee-Chien Yong, Yueh-Wei Liu, Sheng-Nan Lu, Chih-Chi Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/95d77efd1f2c40c8be2deff93a65e991
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spelling	oai:doaj.org-article:95d77efd1f2c40c8be2deff93a65e9912021-12-02T16:31:07ZLiver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection10.1038/s41598-021-85431-y2045-2322https://doaj.org/article/95d77efd1f2c40c8be2deff93a65e9912021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85431-yhttps://doaj.org/toc/2045-2322Abstract Curative resection is recommended for patient with early stage hepatocellular carcinoma (HCC), however, the prognosis is limited by high recurrence rate. This study was to investigate liver stiffness (LS) and metabolic factor in prediction of HCC recurrence for patients with early stage HCC who had undergone curative resection. Consecutive patients with suspicion of HCC who had undergone curative resection were prospectively enrolled. Transient elastography was performed to determine LS pre-operatively. The demographics, clinical characteristics and histological findings were recorded. All patients were followed up regularly until recurrence, death or last visit. Ninety-four patients with early stage HCC were enrolled. LS positively correlated with fibrosis stage (r = 0.666). In a median follow-up of 3.2 years, forty patients developed recurrences including 22 recurrences after 1-year post resection. The 5-year cumulative recurrence rate was 44.2%. LS was the independent factor associated with recurrence. Patients with LS > 8.5 kPa had higher 5-year cumulative recurrence rate (59.8% vs 25.1%, p = 0.007). For the prediction of recurrence after 1-year post resection, LS > 8.5 kPa (hazard ratio 2.72) and homeostatic model assessment for insulin resistance index (HOMA-IR) (hazard ratio 1.24) were independent factors in multivariate analysis. Those patients with both LS > 8.5 kPa and HOMA-IR > 2.3 had the highest recurrence rate after 1-year post resection.Jing-Houng WangWei-Feng LiChee-Chien YongYueh-Wei LiuSheng-Nan LuChih-Chi WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing-Houng Wang Wei-Feng Li Chee-Chien Yong Yueh-Wei Liu Sheng-Nan Lu Chih-Chi Wang Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
description	Abstract Curative resection is recommended for patient with early stage hepatocellular carcinoma (HCC), however, the prognosis is limited by high recurrence rate. This study was to investigate liver stiffness (LS) and metabolic factor in prediction of HCC recurrence for patients with early stage HCC who had undergone curative resection. Consecutive patients with suspicion of HCC who had undergone curative resection were prospectively enrolled. Transient elastography was performed to determine LS pre-operatively. The demographics, clinical characteristics and histological findings were recorded. All patients were followed up regularly until recurrence, death or last visit. Ninety-four patients with early stage HCC were enrolled. LS positively correlated with fibrosis stage (r = 0.666). In a median follow-up of 3.2 years, forty patients developed recurrences including 22 recurrences after 1-year post resection. The 5-year cumulative recurrence rate was 44.2%. LS was the independent factor associated with recurrence. Patients with LS > 8.5 kPa had higher 5-year cumulative recurrence rate (59.8% vs 25.1%, p = 0.007). For the prediction of recurrence after 1-year post resection, LS > 8.5 kPa (hazard ratio 2.72) and homeostatic model assessment for insulin resistance index (HOMA-IR) (hazard ratio 1.24) were independent factors in multivariate analysis. Those patients with both LS > 8.5 kPa and HOMA-IR > 2.3 had the highest recurrence rate after 1-year post resection.
format	article
author	Jing-Houng Wang Wei-Feng Li Chee-Chien Yong Yueh-Wei Liu Sheng-Nan Lu Chih-Chi Wang
author_facet	Jing-Houng Wang Wei-Feng Li Chee-Chien Yong Yueh-Wei Liu Sheng-Nan Lu Chih-Chi Wang
author_sort	Jing-Houng Wang
title	Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
title_short	Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
title_full	Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
title_fullStr	Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
title_full_unstemmed	Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
title_sort	liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95d77efd1f2c40c8be2deff93a65e991
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_version_	1718383888088170496

Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection

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