Pilot in vivo toxicological investigation of boron nitride nanotubes

Gianni Ciofani1, Serena Danti2, Giada Graziana Genchi1,3, Delfo D&#39;Alessandro2, Jean-Luc Pellequer4, Micha&euml;l Odorico4, Virgilio Mattoli1, Mario Giorgi51Italian Institute of Technology, Center of MicroBioRobotics co Scuola Superiore Sant&#39;Anna, 2Department of Neuros...

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Autores principales:	Ciofani G, Danti S, Genchi GG, D&rsquo;Alessandro D, Pellequer JL, Odorico M, Mattoli V, Giorgi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/95d79202107e47f58ccb34838b0ed5cd
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spelling	oai:doaj.org-article:95d79202107e47f58ccb34838b0ed5cd2021-12-02T01:42:38ZPilot in vivo toxicological investigation of boron nitride nanotubes1176-91141178-2013https://doaj.org/article/95d79202107e47f58ccb34838b0ed5cd2012-01-01T00:00:00Zhttp://www.dovepress.com/pilot-in-vivo-toxicological-investigation-of-boron-nitride-nanotubes-a8994https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Gianni Ciofani1, Serena Danti2, Giada Graziana Genchi1,3, Delfo D&#39;Alessandro2, Jean-Luc Pellequer4, Micha&euml;l Odorico4, Virgilio Mattoli1, Mario Giorgi51Italian Institute of Technology, Center of MicroBioRobotics co Scuola Superiore Sant&#39;Anna, 2Department of Neuroscience, University of Pisa, 3The BioRobotics Institute, Scuola Superiore Sant&#39;Anna, Pisa, Italy; 4Commissariat &agrave; l&#39;Energie Atomique, Institut de Biologie Environnementale et Biotechnologie, Department of Biochemistry and Nuclear Toxicology, Bagnols-sur-C&egrave;ze, France; 5Division of Pharmacology and Toxicology, Veterinary Clinics Department, University of Pisa, Pisa, ItalyAbstract: Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibility on many different cell lines. At this point, in vivo investigations are necessary before proceeding toward realistic developments of the proposed applications. In this communication, we report a pilot toxicological study of BNNTs in rabbits. Animals were injected with a 1 mg/kg BNNT solution and blood tests were performed up to 72 hours after injection. The analyses aimed at evaluating any acute alteration of hematic parameters that could represent evidence of functional impairment in blood, liver, and kidneys. Even if preliminary, the data are highly promising, as they showed no adverse effects on all the evaluated parameters, and therefore suggest the possibility of the realistic application of BNNTs in the biomedical field.Keywords: boron nitride nanotubes, in vivo testing, toxicologyCiofani GDanti SGenchi GGD&rsquo;Alessandro DPellequer JLOdorico MMattoli VGiorgi MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 19-24 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ciofani G Danti S Genchi GG D&rsquo;Alessandro D Pellequer JL Odorico M Mattoli V Giorgi M Pilot in vivo toxicological investigation of boron nitride nanotubes
description	Gianni Ciofani1, Serena Danti2, Giada Graziana Genchi1,3, Delfo D&#39;Alessandro2, Jean-Luc Pellequer4, Micha&euml;l Odorico4, Virgilio Mattoli1, Mario Giorgi51Italian Institute of Technology, Center of MicroBioRobotics co Scuola Superiore Sant&#39;Anna, 2Department of Neuroscience, University of Pisa, 3The BioRobotics Institute, Scuola Superiore Sant&#39;Anna, Pisa, Italy; 4Commissariat &agrave; l&#39;Energie Atomique, Institut de Biologie Environnementale et Biotechnologie, Department of Biochemistry and Nuclear Toxicology, Bagnols-sur-C&egrave;ze, France; 5Division of Pharmacology and Toxicology, Veterinary Clinics Department, University of Pisa, Pisa, ItalyAbstract: Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibility on many different cell lines. At this point, in vivo investigations are necessary before proceeding toward realistic developments of the proposed applications. In this communication, we report a pilot toxicological study of BNNTs in rabbits. Animals were injected with a 1 mg/kg BNNT solution and blood tests were performed up to 72 hours after injection. The analyses aimed at evaluating any acute alteration of hematic parameters that could represent evidence of functional impairment in blood, liver, and kidneys. Even if preliminary, the data are highly promising, as they showed no adverse effects on all the evaluated parameters, and therefore suggest the possibility of the realistic application of BNNTs in the biomedical field.Keywords: boron nitride nanotubes, in vivo testing, toxicology
format	article
author	Ciofani G Danti S Genchi GG D&rsquo;Alessandro D Pellequer JL Odorico M Mattoli V Giorgi M
author_facet	Ciofani G Danti S Genchi GG D&rsquo;Alessandro D Pellequer JL Odorico M Mattoli V Giorgi M
author_sort	Ciofani G
title	Pilot in vivo toxicological investigation of boron nitride nanotubes
title_short	Pilot in vivo toxicological investigation of boron nitride nanotubes
title_full	Pilot in vivo toxicological investigation of boron nitride nanotubes
title_fullStr	Pilot in vivo toxicological investigation of boron nitride nanotubes
title_full_unstemmed	Pilot in vivo toxicological investigation of boron nitride nanotubes
title_sort	pilot in vivo toxicological investigation of boron nitride nanotubes
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/95d79202107e47f58ccb34838b0ed5cd
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_version_	1718402909599694848

Pilot in vivo toxicological investigation of boron nitride nanotubes

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