Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression.

<h4>Background</h4>Gliomas are thought to form by clonal expansion from a single cell-of-origin, and progression-associated mutations to occur in its progeny cells. Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf...

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Autores principales: Elena I Fomchenko, Joseph D Dougherty, Karim Y Helmy, Amanda M Katz, Alexander Pietras, Cameron Brennan, Jason T Huse, Ana Milosevic, Eric C Holland
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/95d7ded787264c348290c92103d44730
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