Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.

Guardado en:

Detalles Bibliográficos
Autores principales:	Minh-Thu Nguyen, Julia Uebele, Nimerta Kumari, Hiroshi Nakayama, Lena Peter, Olga Ticha, Anne-Kathrin Woischnig, Mathias Schmaler, Nina Khanna, Naoshi Dohmae, Bok Luel Lee, Isabelle Bekeredjian-Ding, Friedrich Götz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95d81711f93f4c8c8fb6d6efe4302cb2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:95d81711f93f4c8c8fb6d6efe4302cb2
record_format	dspace
spelling	oai:doaj.org-article:95d81711f93f4c8c8fb6d6efe4302cb22021-12-02T13:23:47ZLipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses10.1038/s41467-017-02234-42041-1723https://doaj.org/article/95d81711f93f4c8c8fb6d6efe4302cb22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02234-4https://doaj.org/toc/2041-1723The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.Minh-Thu NguyenJulia UebeleNimerta KumariHiroshi NakayamaLena PeterOlga TichaAnne-Kathrin WoischnigMathias SchmalerNina KhannaNaoshi DohmaeBok Luel LeeIsabelle Bekeredjian-DingFriedrich GötzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minh-Thu Nguyen Julia Uebele Nimerta Kumari Hiroshi Nakayama Lena Peter Olga Ticha Anne-Kathrin Woischnig Mathias Schmaler Nina Khanna Naoshi Dohmae Bok Luel Lee Isabelle Bekeredjian-Ding Friedrich Götz Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
description	The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.
format	article
author	Minh-Thu Nguyen Julia Uebele Nimerta Kumari Hiroshi Nakayama Lena Peter Olga Ticha Anne-Kathrin Woischnig Mathias Schmaler Nina Khanna Naoshi Dohmae Bok Luel Lee Isabelle Bekeredjian-Ding Friedrich Götz
author_facet	Minh-Thu Nguyen Julia Uebele Nimerta Kumari Hiroshi Nakayama Lena Peter Olga Ticha Anne-Kathrin Woischnig Mathias Schmaler Nina Khanna Naoshi Dohmae Bok Luel Lee Isabelle Bekeredjian-Ding Friedrich Götz
author_sort	Minh-Thu Nguyen
title	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_short	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_full	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_fullStr	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_full_unstemmed	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_sort	lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/95d81711f93f4c8c8fb6d6efe4302cb2
work_keys_str_mv	AT minhthunguyen lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT juliauebele lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT nimertakumari lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT hiroshinakayama lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT lenapeter lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT olgaticha lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT annekathrinwoischnig lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT mathiasschmaler lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT ninakhanna lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT naoshidohmae lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT bokluellee lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT isabellebekeredjianding lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses AT friedrichgotz lipidmoietiesonlipoproteinsofcommensalandnoncommensalstaphylococciinducedifferentialimmuneresponses
_version_	1718393167728869376

Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Ejemplares similares