Ni-catalyzed hydroaminoalkylation of alkynes with amines

Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but efficient catalytic systems for hydroaminoalkylation of alkynes are needed. Here, the authors report a late transition metal‐catalyzed hydroaminoalkylation of alkynes with N‐sulfonyl amines, provi...

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Main Authors:	Wei-Wei Yao, Ran Li, Hao Chen, Ming-Kai Chen, Yu-Xin Luan, Yi Wang, Zhi-Xiang Yu, Mengchun Ye
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/95db0d7dc8c1444695587f731b4b144f
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spelling	oai:doaj.org-article:95db0d7dc8c1444695587f731b4b144f2021-12-02T16:06:03ZNi-catalyzed hydroaminoalkylation of alkynes with amines10.1038/s41467-021-24032-92041-1723https://doaj.org/article/95db0d7dc8c1444695587f731b4b144f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24032-9https://doaj.org/toc/2041-1723Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but efficient catalytic systems for hydroaminoalkylation of alkynes are needed. Here, the authors report a late transition metal‐catalyzed hydroaminoalkylation of alkynes with N‐sulfonyl amines, providing a series of allylic amines in up to 94% yield.Wei-Wei YaoRan LiHao ChenMing-Kai ChenYu-Xin LuanYi WangZhi-Xiang YuMengchun YeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei-Wei Yao Ran Li Hao Chen Ming-Kai Chen Yu-Xin Luan Yi Wang Zhi-Xiang Yu Mengchun Ye Ni-catalyzed hydroaminoalkylation of alkynes with amines
description	Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but efficient catalytic systems for hydroaminoalkylation of alkynes are needed. Here, the authors report a late transition metal‐catalyzed hydroaminoalkylation of alkynes with N‐sulfonyl amines, providing a series of allylic amines in up to 94% yield.
format	article
author	Wei-Wei Yao Ran Li Hao Chen Ming-Kai Chen Yu-Xin Luan Yi Wang Zhi-Xiang Yu Mengchun Ye
author_facet	Wei-Wei Yao Ran Li Hao Chen Ming-Kai Chen Yu-Xin Luan Yi Wang Zhi-Xiang Yu Mengchun Ye
author_sort	Wei-Wei Yao
title	Ni-catalyzed hydroaminoalkylation of alkynes with amines
title_short	Ni-catalyzed hydroaminoalkylation of alkynes with amines
title_full	Ni-catalyzed hydroaminoalkylation of alkynes with amines
title_fullStr	Ni-catalyzed hydroaminoalkylation of alkynes with amines
title_full_unstemmed	Ni-catalyzed hydroaminoalkylation of alkynes with amines
title_sort	ni-catalyzed hydroaminoalkylation of alkynes with amines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/95db0d7dc8c1444695587f731b4b144f
work_keys_str_mv	AT weiweiyao nicatalyzedhydroaminoalkylationofalkyneswithamines AT ranli nicatalyzedhydroaminoalkylationofalkyneswithamines AT haochen nicatalyzedhydroaminoalkylationofalkyneswithamines AT mingkaichen nicatalyzedhydroaminoalkylationofalkyneswithamines AT yuxinluan nicatalyzedhydroaminoalkylationofalkyneswithamines AT yiwang nicatalyzedhydroaminoalkylationofalkyneswithamines AT zhixiangyu nicatalyzedhydroaminoalkylationofalkyneswithamines AT mengchunye nicatalyzedhydroaminoalkylationofalkyneswithamines
_version_	1718385162384834560

Ni-catalyzed hydroaminoalkylation of alkynes with amines

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