Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery

Abstract Objective The biological importance for the signaling of C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) has been recognized. However, the details remain unclear and are debatable. The Npr2 is a gene of NPR-B, and we previously reported a unique phenotype of a sp...

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Autores principales:	Chizuru Sogawa-Fujiwara, Yasuhiro Fujiwara, Atsuki Hanagata, Qunhui Yang, Taiki Mihara, Noriyuki Kaji, Tetsuo Kunieda, Masatoshi Hori
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	CNP NPR-B Blood vessel Adipocyte Intestinal disorder Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/95e6fa3bd255440f8470d1b0c10aae6e
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spelling	oai:doaj.org-article:95e6fa3bd255440f8470d1b0c10aae6e2021-11-28T12:24:50ZNpr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery10.1186/s13104-021-05853-91756-0500https://doaj.org/article/95e6fa3bd255440f8470d1b0c10aae6e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13104-021-05853-9https://doaj.org/toc/1756-0500Abstract Objective The biological importance for the signaling of C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) has been recognized. However, the details remain unclear and are debatable. The Npr2 is a gene of NPR-B, and we previously reported a unique phenotype of a spontaneous mutant mouse lacking Npr2 (Npr2 slw/slw ), such as severe ileus-like disorder with bloodless blood vessels. In this study, we analyzed the bloodless mesenteric vascular morphology of Npr2 slw/slw by histological observation to clarify the effects of the CNP/NPR-B signal deficiency. Results Blood vessels in the mesentery were clearly dilated in the preweaning Npr2 slw/slw mice. Additionally, in the Npr2 slw/slw mice, the lacteals were partially dilation or randomly direction mucosal epithelial cells in villi, and mesenteric adipocytes were undeveloped. These findings provide important information for understanding the role of CNP/NPR-B signals on intestine with mesentery.Chizuru Sogawa-FujiwaraYasuhiro FujiwaraAtsuki HanagataQunhui YangTaiki MiharaNoriyuki KajiTetsuo KuniedaMasatoshi HoriBMCarticleCNPNPR-BBlood vesselAdipocyteIntestinal disorderMedicineRBiology (General)QH301-705.5Science (General)Q1-390ENBMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CNP NPR-B Blood vessel Adipocyte Intestinal disorder Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
spellingShingle	CNP NPR-B Blood vessel Adipocyte Intestinal disorder Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 Chizuru Sogawa-Fujiwara Yasuhiro Fujiwara Atsuki Hanagata Qunhui Yang Taiki Mihara Noriyuki Kaji Tetsuo Kunieda Masatoshi Hori Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
description	Abstract Objective The biological importance for the signaling of C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) has been recognized. However, the details remain unclear and are debatable. The Npr2 is a gene of NPR-B, and we previously reported a unique phenotype of a spontaneous mutant mouse lacking Npr2 (Npr2 slw/slw ), such as severe ileus-like disorder with bloodless blood vessels. In this study, we analyzed the bloodless mesenteric vascular morphology of Npr2 slw/slw by histological observation to clarify the effects of the CNP/NPR-B signal deficiency. Results Blood vessels in the mesentery were clearly dilated in the preweaning Npr2 slw/slw mice. Additionally, in the Npr2 slw/slw mice, the lacteals were partially dilation or randomly direction mucosal epithelial cells in villi, and mesenteric adipocytes were undeveloped. These findings provide important information for understanding the role of CNP/NPR-B signals on intestine with mesentery.
format	article
author	Chizuru Sogawa-Fujiwara Yasuhiro Fujiwara Atsuki Hanagata Qunhui Yang Taiki Mihara Noriyuki Kaji Tetsuo Kunieda Masatoshi Hori
author_facet	Chizuru Sogawa-Fujiwara Yasuhiro Fujiwara Atsuki Hanagata Qunhui Yang Taiki Mihara Noriyuki Kaji Tetsuo Kunieda Masatoshi Hori
author_sort	Chizuru Sogawa-Fujiwara
title	Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
title_short	Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
title_full	Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
title_fullStr	Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
title_full_unstemmed	Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
title_sort	npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
publisher	BMC
publishDate	2021
url	https://doaj.org/article/95e6fa3bd255440f8470d1b0c10aae6e
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_version_	1718407970632499200

Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery

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