Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determ...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:95e8345babf04292a31f57b9c017f30a2021-11-17T06:44:17ZPotential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine1664-322410.3389/fimmu.2021.765528https://doaj.org/article/95e8345babf04292a31f57b9c017f30a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.765528/fullhttps://doaj.org/toc/1664-3224Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated de novo vaccinations.Alissa CaitAnna MooneyAnna MooneyHazel PoyntzHazel PoyntzNick ShorttNick ShorttAngela JonesAngela JonesAurélie GestinAurélie GestinKatie GellAlix GroobyDavid O’SullivanDavid O’SullivanJeffry S. TangJeffry S. TangWayne YoungWayne YoungDarmiga ThayabaranDarmiga ThayabaranJenny SparksJenny SparksTess OstapowiczTess OstapowiczAudrey TayAudrey TaySally D. PoppittSally D. PoppittSarah ElliottSarah ElliottGeorgia WakefieldGeorgia WakefieldAmber Parry-StrongAmber Parry-StrongJacqui RalstonRichard BeasleyRichard BeasleyMark WeatherallIrene BraithwaiteIrene BraithwaiteElizabeth Forbes-BlomElizabeth Forbes-BlomOlivier GasserOlivier GasserFrontiers Media S.A.articlefibremicrobiomeinfluenzavaccineshort chain fatty acids (SCFA)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
fibre microbiome influenza vaccine short chain fatty acids (SCFA) Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
fibre microbiome influenza vaccine short chain fatty acids (SCFA) Immunologic diseases. Allergy RC581-607 Alissa Cait Anna Mooney Anna Mooney Hazel Poyntz Hazel Poyntz Nick Shortt Nick Shortt Angela Jones Angela Jones Aurélie Gestin Aurélie Gestin Katie Gell Alix Grooby David O’Sullivan David O’Sullivan Jeffry S. Tang Jeffry S. Tang Wayne Young Wayne Young Darmiga Thayabaran Darmiga Thayabaran Jenny Sparks Jenny Sparks Tess Ostapowicz Tess Ostapowicz Audrey Tay Audrey Tay Sally D. Poppitt Sally D. Poppitt Sarah Elliott Sarah Elliott Georgia Wakefield Georgia Wakefield Amber Parry-Strong Amber Parry-Strong Jacqui Ralston Richard Beasley Richard Beasley Mark Weatherall Irene Braithwaite Irene Braithwaite Elizabeth Forbes-Blom Elizabeth Forbes-Blom Olivier Gasser Olivier Gasser Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine |
| description |
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated de novo vaccinations. |
| format |
article |
| author |
Alissa Cait Anna Mooney Anna Mooney Hazel Poyntz Hazel Poyntz Nick Shortt Nick Shortt Angela Jones Angela Jones Aurélie Gestin Aurélie Gestin Katie Gell Alix Grooby David O’Sullivan David O’Sullivan Jeffry S. Tang Jeffry S. Tang Wayne Young Wayne Young Darmiga Thayabaran Darmiga Thayabaran Jenny Sparks Jenny Sparks Tess Ostapowicz Tess Ostapowicz Audrey Tay Audrey Tay Sally D. Poppitt Sally D. Poppitt Sarah Elliott Sarah Elliott Georgia Wakefield Georgia Wakefield Amber Parry-Strong Amber Parry-Strong Jacqui Ralston Richard Beasley Richard Beasley Mark Weatherall Irene Braithwaite Irene Braithwaite Elizabeth Forbes-Blom Elizabeth Forbes-Blom Olivier Gasser Olivier Gasser |
| author_facet |
Alissa Cait Anna Mooney Anna Mooney Hazel Poyntz Hazel Poyntz Nick Shortt Nick Shortt Angela Jones Angela Jones Aurélie Gestin Aurélie Gestin Katie Gell Alix Grooby David O’Sullivan David O’Sullivan Jeffry S. Tang Jeffry S. Tang Wayne Young Wayne Young Darmiga Thayabaran Darmiga Thayabaran Jenny Sparks Jenny Sparks Tess Ostapowicz Tess Ostapowicz Audrey Tay Audrey Tay Sally D. Poppitt Sally D. Poppitt Sarah Elliott Sarah Elliott Georgia Wakefield Georgia Wakefield Amber Parry-Strong Amber Parry-Strong Jacqui Ralston Richard Beasley Richard Beasley Mark Weatherall Irene Braithwaite Irene Braithwaite Elizabeth Forbes-Blom Elizabeth Forbes-Blom Olivier Gasser Olivier Gasser |
| author_sort |
Alissa Cait |
| title |
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine |
| title_short |
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine |
| title_full |
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine |
| title_fullStr |
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine |
| title_full_unstemmed |
Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine |
| title_sort |
potential association between dietary fibre and humoral response to the seasonal influenza vaccine |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/95e8345babf04292a31f57b9c017f30a |
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