c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.

c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.

<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive death of motor neurons. Although the pathogenesis of ALS remains unclear, several cellular processes are known to be involved, including apoptosis. A previous study re...

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Autores principales: Ryu Katsumata, Shinsuke Ishigaki, Masahisa Katsuno, Kaori Kawai, Jun Sone, Zhe Huang, Hiroaki Adachi, Fumiaki Tanaka, Fumihiko Urano, Gen Sobue
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/95e88ca923da4d248ec144fba0ba317b
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