Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis

Objective To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. Methods This retrospective case–control study analysed data from patients with SCA that experienced VTE compared with...

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Autores principales:	Salam Alkindi, Anwaar R Al-Ghadani, Samah R Al-Zeheimi, Said Y Alkindi, Naglaa Fawaz, Samir K Ballas, Anil V Pathare
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/95ea4dfd75d2493b9f26a8775569912b
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spelling	oai:doaj.org-article:95ea4dfd75d2493b9f26a8775569912b2021-12-03T01:03:33ZPredicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis1473-230010.1177/03000605211055385https://doaj.org/article/95ea4dfd75d2493b9f26a8775569912b2021-12-01T00:00:00Zhttps://doi.org/10.1177/03000605211055385https://doaj.org/toc/1473-2300Objective To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. Methods This retrospective case–control study analysed data from patients with SCA that experienced VTE compared with matched control patients with SCA but no VTE (2:1 ratio). Results A total of 102 patients with SCA were enrolled (68 cases with VTE and 34 controls). Amongst the 68 cases (median age, 29.5 years), 26 (38.2%) presented with isolated pulmonary embolism (PE). A higher prevalence of splenectomy (73.5% versus 35.3%) was observed in the cases compared with the controls. A significantly higher prevalence of central venous catheter (CVC) insertion (42.6% versus 8.8%) was observed in the cases compared with the controls. High white blood cell counts, serum lactic dehydrogenase (LDH), bilirubin and C-reactive protein (CRP) and low haemoglobin (Hb) and HbF were significant risk factors for VTE. Forty-two cases (61.8%) developed acute chest syndrome, 10 (14.7%) had a stroke and seven (10.3%) died. Conclusions VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors.Salam AlkindiAnwaar R Al-GhadaniSamah R Al-ZeheimiSaid Y AlkindiNaglaa FawazSamir K BallasAnil V PathareSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Salam Alkindi Anwaar R Al-Ghadani Samah R Al-Zeheimi Said Y Alkindi Naglaa Fawaz Samir K Ballas Anil V Pathare Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
description	Objective To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. Methods This retrospective case–control study analysed data from patients with SCA that experienced VTE compared with matched control patients with SCA but no VTE (2:1 ratio). Results A total of 102 patients with SCA were enrolled (68 cases with VTE and 34 controls). Amongst the 68 cases (median age, 29.5 years), 26 (38.2%) presented with isolated pulmonary embolism (PE). A higher prevalence of splenectomy (73.5% versus 35.3%) was observed in the cases compared with the controls. A significantly higher prevalence of central venous catheter (CVC) insertion (42.6% versus 8.8%) was observed in the cases compared with the controls. High white blood cell counts, serum lactic dehydrogenase (LDH), bilirubin and C-reactive protein (CRP) and low haemoglobin (Hb) and HbF were significant risk factors for VTE. Forty-two cases (61.8%) developed acute chest syndrome, 10 (14.7%) had a stroke and seven (10.3%) died. Conclusions VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors.
format	article
author	Salam Alkindi Anwaar R Al-Ghadani Samah R Al-Zeheimi Said Y Alkindi Naglaa Fawaz Samir K Ballas Anil V Pathare
author_facet	Salam Alkindi Anwaar R Al-Ghadani Samah R Al-Zeheimi Said Y Alkindi Naglaa Fawaz Samir K Ballas Anil V Pathare
author_sort	Salam Alkindi
title	Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_short	Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_full	Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_fullStr	Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_full_unstemmed	Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_sort	predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/95ea4dfd75d2493b9f26a8775569912b
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Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis

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